Do cannabinoids have a therapeutic role in transplantation?
Language: 
English
Abstract: 

Cannabinoids have emerged as powerful drug candidates for the treatment of inflammatory and autoimmune diseases due to their immunosuppressive properties. Significant clinical and experimental data on the use of cannabinoids as anti-inflammatory agents exist in many autoimmune disease settings, but virtually no studies have been undertaken on their potential role in transplant rejection. Here we suggest a theoretical role for the use of cannabinoids in preventing allograft rejection. The psychotropic properties of CB1 agonists limit their clinical use, but CB2 agonists may offer a new avenue to selectively target immune cells involved in allograft rejection. Moreover, development of mixed CB1/CB2 agonists that cannot cross the blood-brain barrier may help prevent their undesired psychotropic properties. In addition, manipulation of endocannabinoids in vivo by activating their biosynthesis and inhibiting cellular uptake and metabolism may offer another pathway to regulate immune response during allograft rejection.

Author(s): 
Nagarkatti, Mitzi
Rieder, Sadiye Amcaoglu
Hegde, Venkatesh L.
Kanada, Shunsuke
Nagarkatti, Prakash
Item Type: 
Journal Article
Publication Title: 
Trends in Pharmacological Sciences
Journal Abbreviation: 
Trends Pharmacol. Sci.
Publication Date: 
Aug 2010
Publication Year: 
2010
Pages: 
345-350
Volume: 
31
Issue: 
8
ISSN: 
1873-3735
DOI: 
10.1016/j.tips.2010.05.006
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 20591510 PMCID: PMC2923447

Turabian/Chicago Citation

Mitzi Nagarkatti, Sadiye Amcaoglu Rieder, Venkatesh L. Hegde, Shunsuke Kanada and Prakash Nagarkatti. Aug 2010. "Do cannabinoids have a therapeutic role in transplantation?." Trends in Pharmacological Sciences 31: 8: 345-350. 10.1016/j.tips.2010.05.006.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.tips.2010.05.006 | issn = 1873-3735 | volume = 31 | pages = 345-350 | last = Nagarkatti | first = Mitzi | coauthors = Rieder, Sadiye Amcaoglu, Hegde, Venkatesh L., Kanada, Shunsuke, Nagarkatti, Prakash | title = Do cannabinoids have a therapeutic role in transplantation? | journal = Trends in Pharmacological Sciences | date = Aug 2010 | pmid = | pmc = }} </ref>