Early life undernutrition alters the level of reduced glutathione but not the activity levels of reactive oxygen species enzymes or lipid peroxidation in the mouse forebrain
Language: 
English
Abstract: 

Diet restriction of rodents during adult life is known to cause an increased life span. It has been hypothesised that this increase may be related to effects on the anti-oxidant defence systems. However, it has been suggested that undernutrition during the gestation and pre-weaning may reduce their life span as it is known to have other deleterious effects on a rodent's growth and development. We have now examined the activity levels of some anti-oxidant defence system enzymes and other markers of oxidative stress in mice that have been undernourished from conception until 21 postnatal days of age, followed in some cases by a period of nutritional rehabilitation until 61 days of age. We found that such undernutrition exerted only minimal effects on oxidative stress markers under investigation (ROS enzyme activities, GSH levels, and lipid peroxidation). Only GSH levels were significantly affected by pre-weaning undernutrition. In conclusion, pre-weaning undernutrition may regulate anti-oxidant enzymes at the transcriptional level differently from that at the post-transcriptional, translational, or post-translational levels. The possible effects that these changes at the cellular level, may have on the longevity of the animals remain of great interest and importance.

Author(s): 
Partadiredja, G.
Worrall, S.
Bedi, K. S.
Item Type: 
Journal Article
Publication Title: 
Brain Research
Journal Abbreviation: 
Brain Res.
Publication Date: 
8/18/2009
Publication Year: 
2009
Pages: 
22-29
Volume: 
1285
ISSN: 
1872-6240
DOI: 
10.1016/j.brainres.2009.06.010
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 19524562

Turabian/Chicago Citation

G. Partadiredja, S. Worrall and K. S. Bedi. 8/18/2009. "Early life undernutrition alters the level of reduced glutathione but not the activity levels of reactive oxygen species enzymes or lipid peroxidation in the mouse forebrain." Brain Research 1285: 22-29. 10.1016/j.brainres.2009.06.010.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.brainres.2009.06.010 | issn = 1872-6240 | volume = 1285 | pages = 22-29 | last = Partadiredja | first = G. | coauthors = Worrall, S., Bedi, K. S. | title = Early life undernutrition alters the level of reduced glutathione but not the activity levels of reactive oxygen species enzymes or lipid peroxidation in the mouse forebrain | journal = Brain Research | date = 8/18/2009 | pmid = | pmc = }} </ref>