Effect of antimalarial drugs on plasmodia cell-free protein synthesis
Language: 
English
Abstract: 

A cell-free system from Plasmodium falciparum able to translate endogenous mRNA was used to determine the effect of artemisinin, chloroquine and primaquine on the protein synthesis mechanism of the parasite. The antimalarial drugs did not inhibit the incorporation of [3H] methionine into parasite proteins even at concentrations higher than the ones found to strongly inhibit the parasite growth. Results clearly indicate that these compounds do not have a direct effect on protein synthesis activity of P. falciparum coded by endogenous mRNA.

Author(s): 
Ferreras, Ana
Triana, Ledia
Sánchez, Erlinda
Herrera, Flor
Item Type: 
Journal Article
Publication Title: 
Memórias Do Instituto Oswaldo Cruz
Journal Abbreviation: 
Mem. Inst. Oswaldo Cruz
Publication Date: 
4/2/2015
Publication Year: 
2002
Pages: 
377-380
Volume: 
97
Issue: 
3
ISSN: 
0074-0276
Library Catalog: 
PubMed
Extra: 
PMID: 12048568

Turabian/Chicago Citation

Ana Ferreras, Ledia Triana, Erlinda Sánchez and Flor Herrera. 4/2/2015. "Effect of antimalarial drugs on plasmodia cell-free protein synthesis." Memórias Do Instituto Oswaldo Cruz 97: 3: 377-380.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 0074-0276 | volume = 97 | pages = 377-380 | last = Ferreras | first = Ana | coauthors = Triana, Ledia, Sánchez, Erlinda, Herrera, Flor | title = Effect of antimalarial drugs on plasmodia cell-free protein synthesis | journal = Memórias Do Instituto Oswaldo Cruz | date = 4/2/2015 | pmid = | pmc = }} </ref>