Effect of bioactive tannoid principles of Emblica officinalis on iron-induced hepatic toxicity in rats
Language: 
English
Abstract: 

The tannoid principles of the fruits of the plant Emblica officinalis Gaertn comprising of emblicanin A. emblicanin B, punigluconin and pedunculagin, have been reported to exhibit antioxidant activity in vitro and in vivo. In the present study, an emblicanin A (37%) and B (33%) enriched fraction of fresh juice of Emblica fruits (EOT), administered prophylactically (10, 20 and 50 mg/kg, p.o.) for 10 consecutive day, was found to inhibit acute iron overload (30 mg/kg, i.p.) hepatic lipid peroxidation and the increase of serum levels of alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase, used as markers of the induced hepatic dysfunction. A similar effect was produced by silymarin (20 mg/kg, p.o.), an antioxidant hepatoprotective agent. The results support the use of Emblica fruits for hepatoprotection in Ayurveda.

Author(s): 
Bhattacharya, A.
Kumar, M.
Ghosal, S.
Bhattacharya, S. K.
Item Type: 
Journal Article
Publication Title: 
Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Journal Abbreviation: 
Phytomedicine
Publication Date: 
Apr 2000
Publication Year: 
2000
Pages: 
173-175
Volume: 
7
Issue: 
2
ISSN: 
0944-7113
DOI: 
10.1016/S0944-7113(00)80091-4
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 10839222

Turabian/Chicago Citation

A. Bhattacharya, M. Kumar, S. Ghosal and S. K. Bhattacharya. Apr 2000. "Effect of bioactive tannoid principles of Emblica officinalis on iron-induced hepatic toxicity in rats." Phytomedicine: International Journal of Phytotherapy and Phytopharmacology 7: 2: 173-175. 10.1016/S0944-7113(00)80091-4.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/S0944-7113(00)80091-4 | issn = 0944-7113 | volume = 7 | pages = 173-175 | last = Bhattacharya | first = A. | coauthors = Kumar, M., Ghosal, S., Bhattacharya, S. K. | title = Effect of bioactive tannoid principles of Emblica officinalis on iron-induced hepatic toxicity in rats | journal = Phytomedicine: International Journal of Phytotherapy and Phytopharmacology | date = Apr 2000 | pmid = | pmc = }} </ref>