Effect of Cinnamomum cassia methanol extract and sildenafil on arginase and sexual function of young male Wistar rats
Language: 
English
Abstract: 

INTRODUCTION: Herbs have been used as an aphrodisiac since ages. Cinnamomum cassia is an important ingredient of many Ayurvedic formulations to treat male sexual disorder including erectile dysfunction (ED). AIM: The objective of the present study was to evaluate erectogenic and aphrodisiac activity of methanol extract of C. cassia bark in young male rats. METHODS: Methanol extract of C. cassia was screened in vitro for arginase inhibition potential and IC50 was determined. Effect of the extract was observed in vitro on phenylephrine pre-contracted isolated rat corpus cavernosum smooth muscle (CCSM) at 0.1, 1, 10, and 100 μg/mL. Young male Wistar rats were dosed with extract at 100 mg/kg body weight for 28 days and its effects on sexual behavior and penile smooth muscle : collagen level were observed. MAIN OUTCOME MEASURE: Effect of C. cassia was studied on arginase activity in vitro and sexual behavior of young male rats. RESULTS: C. cassia inhibited arginase activity in vitro with an IC50 of 61.72 ± 2.20 μg/mL. The extract relaxed phenylephrine pre-contracted isolated rat CCSM up to 43% and significantly increased (P < 0.05) sexual function of young male rats. Treatment with the extract also increased smooth muscle level and decreased collagen level in rat penile tissue. CONCLUSION: The study proves usefulness of methanol extract of C. cassia bark for increasing sexual function.

Author(s): 
Goswami, Sumanta K.
Inamdar, Mohammed N.
Jamwal, Rohitash
Dethe, Shekhar
Item Type: 
Journal Article
Publication Title: 
The Journal of Sexual Medicine
Journal Abbreviation: 
J Sex Med
Publication Date: 
Jun 2014
Publication Year: 
2014
Pages: 
1475-1483
Volume: 
11
Issue: 
6
ISSN: 
1743-6109
DOI: 
10.1111/jsm.12535
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 24758372

Turabian/Chicago Citation

Sumanta K. Goswami, Mohammed N. Inamdar, Rohitash Jamwal and Shekhar Dethe. Jun 2014. "Effect of Cinnamomum cassia methanol extract and sildenafil on arginase and sexual function of young male Wistar rats." The Journal of Sexual Medicine 11: 6: 1475-1483. 10.1111/jsm.12535.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1111/jsm.12535 | issn = 1743-6109 | volume = 11 | pages = 1475-1483 | last = Goswami | first = Sumanta K. | coauthors = Inamdar, Mohammed N., Jamwal, Rohitash, Dethe, Shekhar | title = Effect of Cinnamomum cassia methanol extract and sildenafil on arginase and sexual function of young male Wistar rats | journal = The Journal of Sexual Medicine | date = Jun 2014 | pmid = | pmc = }} </ref>