Effect of dietary supplements in reducing probability of death for uremic crises in dogs affected by chronic kidney disease (masked RCCT)
Language: 
English
Abstract: 

Chitosan and alkalinizing agents can decrease morbidity and mortality in humans with chronic kidney disease (CKD). Whether this holds true in dog is not known. Objective of the study was to determine whether a commercial dietary supplement containing chitosan, phosphate binders, and alkalinizing agents (Renal), compared to placebo, reduces mortality rate due to uremic crises in dogs with spontaneous CKD, fed a renal diet (RD). A masked RCCT was performed including 31 azotemic dogs with spontaneous CKD. Dogs enrolled in the study were randomly allocated to receive RD plus placebo (group A; 15 dogs) or RD plus Renal (group B; 16 dogs). During a first 4-week period, all dogs were fed an RD and then randomized and clinically evaluated up to 44 weeks. The effects of dietary supplements on mortality rate due to uremic crises were assessed. At 44 weeks, compared to group A, dogs in group B had approximately 50% lower mortality rate due to uremic crises (P = 0.015). Dietary supplementation with chitosan, phosphate binders, and alkalinizing agents, along with an RD, is beneficial in reducing mortality rate in dogs with spontaneous CKD.

Author(s): 
Zatelli, Andrea
Pierantozzi, Marco
D'Ippolito, Paola
Bigliati, Mauro
Zini, Eric
Item Type: 
Journal Article
Publication Title: 
TheScientificWorldJournal
Journal Abbreviation: 
ScientificWorldJournal
Publication Date: 
2012
Publication Year: 
2012
Pages: 
219082
Volume: 
2012
ISSN: 
1537-744X
DOI: 
10.1100/2012/219082
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 22593665 PMCID: PMC3348639

Turabian/Chicago Citation

Andrea Zatelli, Marco Pierantozzi, Paola D'Ippolito, Mauro Bigliati and Eric Zini. 2012. "Effect of dietary supplements in reducing probability of death for uremic crises in dogs affected by chronic kidney disease (masked RCCT)." TheScientificWorldJournal 2012: 219082. 10.1100/2012/219082.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1100/2012/219082 | issn = 1537-744X | volume = 2012 | pages = 219082 | last = Zatelli | first = Andrea | coauthors = Pierantozzi, Marco, D'Ippolito, Paola, Bigliati, Mauro, Zini, Eric | title = Effect of dietary supplements in reducing probability of death for uremic crises in dogs affected by chronic kidney disease (masked RCCT) | journal = TheScientificWorldJournal | date = 2012 | pmid = | pmc = }} </ref>