Effect of Terminalia chebula aqueous extract on oxidative stress and antioxidant status in the liver and kidney of young and aged rats
Language: 
English
Abstract: 

We evaluated the preventive effects of Terminalia chebula (T. chebula) aqueous extract on oxidative and antioxidative status in liver and kidney of aged rats compared to young albino rats. The concentrations of malondialdehyde (MDA), lipofuscin (LF), protein carbonyls (PCO), activities of xantione oxidase (XO), manganese-superoxide dismutase (MnSOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST), and glucose-6-phosphate dehydrogenase (G6PDH), levels of glutathione (GSH), vitamin C and vitamin E were used as biomarkers. In the liver and kidney of aged animals, enhanced oxidative stress was accompanied by compromised antioxidant defences. Administration of aqueous extract of T. cheubla effectively modulated oxidative stress and enhanced antioxidant status in the liver and kidney of aged rats. The results of the present study demonstrate that aqueous extract of T. cheubla inhibits the development of age-induced damages by protecting against oxidative stress.

Author(s): 
Mahesh, Ramalingam
Bhuvana, Shanmugham
Begum, Vava Mohaideen Hazeena
Item Type: 
Journal Article
Publication Title: 
Cell Biochemistry and Function
Journal Abbreviation: 
Cell Biochem. Funct.
Publication Date: 
2009-08
Publication Year: 
2009
Pages: 
358-363
Volume: 
27
Issue: 
6
ISSN: 
1099-0844
DOI: 
10.1002/cbf.1581
Library Catalog: 
PubMed
Extra: 
PMID: 19548245

Turabian/Chicago Citation

Ramalingam Mahesh, Shanmugham Bhuvana and Vava Mohaideen Hazeena Begum. 2009-08. "Effect of Terminalia chebula aqueous extract on oxidative stress and antioxidant status in the liver and kidney of young and aged rats." Cell Biochemistry and Function 27: 6: 358-363. 10.1002/cbf.1581.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1002/cbf.1581 | issn = 1099-0844 | volume = 27 | pages = 358-363 | last = Mahesh | first = Ramalingam | coauthors = Bhuvana, Shanmugham, Begum, Vava Mohaideen Hazeena | title = Effect of Terminalia chebula aqueous extract on oxidative stress and antioxidant status in the liver and kidney of young and aged rats | journal = Cell Biochemistry and Function | date = 2009-08 | pmid = | pmc = }} </ref>