Effectiveness of Cissampelos sympodialis and its isolated alkaloid warifteine in airway hyperreactivity and lung remodeling in a mouse model of asthma
Language: 
English
Abstract: 

BACKGROUND: Cissampelos sympodialis Eichl. (Menispermaceae) is a plant found in Northeastern and Southeast of Brazil and hot water infusion of C. sympodialis root bark is largely used in the indigenous and folk medicine to treat several inflammatory disorders, including asthma. Asthma is a chronic inflammatory allergic disease characterized by airway hyperreactivity (AHR), eosinophil tissue infiltration and lung remodeling. The aim of this study was to evaluate the therapeutic effect of C. sympodialis and its isolated alkaloid warifteine on allergen triggered airway hyperreactivity (AHR) and lung remodeling in murine model of asthma. METHODOLOGY/PRINCIPAL FINDINGS: The oral pre-treatment with C. sympodialis or warifteine inhibited allergen-induced AHR to inhaled methacholine and IL-13 levels in the bronchoalveolar lavage (BAL). In order to investigate the therapeutic potential of C. sympodialis and warifteine, animals were treated 1h after the last ovalbumin (OVA) challenge in sensitized animals. Similarly to the pre-treatment, post-treatment with warifteine was effective to inhibit significantly AHR to inhaled methacholine and to reduce IL-13 levels in the BAL. In addition, oral pre- or post-treatments with C. sympodialis or warifteine reduced OVA-induced eosinophil tissue infiltration, mucus production and subepithelial fibrosis to values similar to nonallergic controls. CONCLUSIONS: Our data show the anti-allergic and immunoregulatory properties of C. sympodialis, acting mostly through the active compound warifteine, to inhibit the airway hyperreactivity and lung remodeling through a mechanism at least partially dependent of IL-13 and eosinophil inhibition. Therefore placing warifteine as an interesting therapeutic candidate in allergic inflammation and corroborating the folk medicine use of C. sympodialis as anti-allergic plant.

Author(s): 
Bezerra-Santos, Claudio R.
Vieira-de-Abreu, Adriana
Vieira, Giciane Carvalho
Filho, Jaime R.
Barbosa-Filho, José Maria
Pires, Ana Lucia
Martins, Marco Aurelio
Souza, Heitor S.
Bandeira-Melo, Christianne
Bozza, Patrícia T.
Piuvezam, Marcia R.
Item Type: 
Journal Article
Publication Title: 
International Immunopharmacology
Journal Abbreviation: 
Int. Immunopharmacol.
Publication Date: 
Jun 2012
Publication Year: 
2012
Pages: 
148-155
Volume: 
13
Issue: 
2
ISSN: 
1878-1705
DOI: 
10.1016/j.intimp.2012.03.014
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 22480776

Turabian/Chicago Citation

Claudio R. Bezerra-Santos, Adriana Vieira-de-Abreu, Giciane Carvalho Vieira, Jaime R. Filho, José Maria Barbosa-Filho, Ana Lucia Pires, Marco Aurelio Martins, Heitor S. Souza, Christianne Bandeira-Melo, Patrícia T. Bozza and Marcia R. Piuvezam. Jun 2012. "Effectiveness of Cissampelos sympodialis and its isolated alkaloid warifteine in airway hyperreactivity and lung remodeling in a mouse model of asthma." International Immunopharmacology 13: 2: 148-155. 10.1016/j.intimp.2012.03.014.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.intimp.2012.03.014 | issn = 1878-1705 | volume = 13 | pages = 148-155 | last = Bezerra-Santos | first = Claudio R. | coauthors = Vieira-de-Abreu, Adriana, Vieira, Giciane Carvalho, Filho, Jaime R., Barbosa-Filho, José Maria, Pires, Ana Lucia, Martins, Marco Aurelio, Souza, Heitor S., Bandeira-Melo, Christianne, Bozza, Patrícia T., Piuvezam, Marcia R. | title = Effectiveness of Cissampelos sympodialis and its isolated alkaloid warifteine in airway hyperreactivity and lung remodeling in a mouse model of asthma | journal = International Immunopharmacology | date = Jun 2012 | pmid = | pmc = }} </ref>