Effector T-cell subsets in systemic lupus erythematosus: update focusing on Th17 cells
Language: 
English
Short Title: 
Effector T-cell subsets in systemic lupus erythematosus
Abstract: 

PURPOSE OF REVIEW: The discovery of T helper (Th)17 cells that produce the proinflammatory cytokine IL-17 has substantially advanced our understanding of T-cell biology and autoimmunity. We will review recent findings on effector T cells, in particular Th17 cells, in lupus. RECENT FINDINGS: Studies reported increased IL-17 levels in the circulation and tissues in human and murine lupus. Patients with systemic lupus erythematosus (SLE or lupus) had an increased frequency of Th17 cells in peripheral blood which correlated with disease activity. However, the frequency of IFN-γ-producing Th1 cells did not change in the same patients, suggesting a selective dysregulation of Th17 cells in SLE. In addition, patients with SLE had an increased frequency of IL-17-producing CD3CD4CD8 (double negative) T cells in the peripheral blood and kidneys. Similar findings were noticed in lupus-prone MRL/MP-lpr/lpr (MRL/lpr) mice. A recent study demonstrated that IL-17 could promote B-cell survival and differentiation into antibody-producing cells. This raises the possibility that IL-17 is implicated in the pathogenesis of SLE by promoting humoral immunity against self-antigen. SUMMARY: Emerging data show a body of evidence that IL-17 and Th17 cells may play a role in the pathogenesis of SLE. Further studies are warranted to dissect the mechanism for increased IL-17 production and the therapeutic implication of targeting this cytokine in SLE.

Author(s): 
Shin, Min S.
Lee, Naeun
Kang, Insoo
Item Type: 
Journal Article
Publication Title: 
Current Opinion in Rheumatology
Journal Abbreviation: 
Curr Opin Rheumatol
Publication Date: 
Sep 2011
Publication Year: 
2011
Pages: 
444-448
Volume: 
23
Issue: 
5
ISSN: 
1531-6963
DOI: 
10.1097/BOR.0b013e328349a255
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 21720245 PMCID: PMC3489922

Turabian/Chicago Citation

Min S. Shin, Naeun Lee and Insoo Kang. Sep 2011. "Effector T-cell subsets in systemic lupus erythematosus: update focusing on Th17 cells." Current Opinion in Rheumatology 23: 5: 444-448. 10.1097/BOR.0b013e328349a255.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1097/BOR.0b013e328349a255 | issn = 1531-6963 | volume = 23 | pages = 444-448 | last = Shin | first = Min S. | coauthors = Lee, Naeun, Kang, Insoo | title = Effector T-cell subsets in systemic lupus erythematosus: update focusing on Th17 cells | journal = Current Opinion in Rheumatology | date = Sep 2011 | pmid = | pmc = }} </ref>