Effects of intramuscular administration of lidocaine or bupivacaine on induction and maintenance doses of propofol evaluated by bispectral index
Language: 
English
Abstract: 

BACKGROUND: Interest in combining local and general anaesthesia has lead to studies investigating possible interactions. In a prospective, randomized, double-blind study, we tested whether local anaesthetics administered i.m. potentiate the hypnotic effect of propofol. METHODS: Sixty patients (three groups, n=20) undergoing lower abdominal surgery with total i.v. propofol anaesthesia were investigated. Patients in Group B received i.m. bupivacaine (5 mg ml(-1)) 1 mg kg(-1), patients in Group L received i.m. lidocaine (100 mg ml(-1)) 2 mg kg(-1) and patients in Group C received i.m. saline 5 ml before operation. Hypnosis was measured with bispectral index (BIS). RESULTS: The induction (BIS <45), and the maintenance doses of propofol (BIS between 40 and 50) were significantly less in Group B and Group L compared with the control group. Induction doses were 1.58 (SD 0.39), 1.56 (0.24) and 2.03 (0.33) mg kg(-1) respectively; P<0.0001. Maintenance doses were 6.33 (2.06), 7.08 (1.23) and 9.95 (2.02) mg kg(-1) respectively in the first hour; P<0.0001. Groups B and L were associated with an attenuated haemodynamic response to both induction and intubation. CONCLUSION: I.M. administered local anaesthetics are associated with a decrease in both the induction and maintenance doses of propofol during total i.v. anaesthesia and a reduction in haemodynamic responses.

Author(s): 
Senturk, M.
Pembeci, K.
Menda, F.
Ozkan, T.
Gucyetmez, B.
Tugrul, M.
Camci, E.
Akpir, K.
Item Type: 
Journal Article
Publication Title: 
British Journal of Anaesthesia
Journal Abbreviation: 
Br J Anaesth
Publication Date: 
12/2/2015
Publication Year: 
2002
Pages: 
849-852
Volume: 
89
Issue: 
6
ISSN: 
0007-0912
Library Catalog: 
PubMed
Extra: 
PMID: 12453928

Turabian/Chicago Citation

M. Senturk, K. Pembeci, F. Menda, T. Ozkan, B. Gucyetmez, M. Tugrul, E. Camci and K. Akpir. 12/2/2015. "Effects of intramuscular administration of lidocaine or bupivacaine on induction and maintenance doses of propofol evaluated by bispectral index." British Journal of Anaesthesia 89: 6: 849-852.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 0007-0912 | volume = 89 | pages = 849-852 | last = Senturk | first = M. | coauthors = Pembeci, K., Menda, F., Ozkan, T., Gucyetmez, B., Tugrul, M., Camci, E., Akpir, K. | title = Effects of intramuscular administration of lidocaine or bupivacaine on induction and maintenance doses of propofol evaluated by bispectral index | journal = British Journal of Anaesthesia | date = 12/2/2015 | pmid = | pmc = }} </ref>