Effects of non-pharmacological supportive care for hot flushes in breast cancer: a meta-analysis
Language: 
English
Short Title: 
Effects of non-pharmacological supportive care for hot flushes in breast cancer
Abstract: 

PURPOSE: To assess the efficacy of non-pharmacological therapies for hot flushes (HFs) in women with breast cancer (BC). METHODS: Nine databases (MEDLINE, Cochrane Central Register of Controlled Trials, EMBASE, PsycINFO, CINAHL, China National Knowledge Infrastructure (CNKI), Chinese Scientific Journal Database (VIP), China Biology Medicine (CBM), and Wan Fang Database) were searched from their inceptions to October 2016. We also hand-searched reference lists of reviews and included articles, reviewed conference proceedings, and contacted experts. Finally, randomized controlled trials (RCTs) were aggregated to evaluate the therapeutic effect of acupuncture for HFs in women with BC. RESULTS: Sixteen trials were included in the meta-analysis. Significant combined effects of non-pharmacological therapies were observed in reducing frequency and severity of HFs after treatment (d = -0.57, P < 0.001). These effects were sustained, albeit reduced in part, during follow-up (d = -0.36, P < 0.001), with the exception of frequency (P = 0.41). Meta-analysis according to therapy types showed that for hypnosis, HFs scores instead of scores of HFs-related daily interference scale (HFRDIS) were significantly lowered at the post-treatment time point (d = -13.19, P < 0.001); for acupuncture, a small but significant effect on HFRDIS was found at the post-treatment time point (d = -3.34, P < 0.001). The effect was sustained during follow-up; however, no effect was evident for HFs frequency; for cognitive behavioral therapy (CBT), at the post-treatment time point, but not during follow-up, a small but significant effect was documented for HFs score (d = -0.88, P < 0.01). No serious adverse effect was reported in the included studies. CONCLUSIONS: Various types of non-pharmacological therapies were associated with significant effects on HFs in women with BC.

Author(s): 
Tao, Wei-Wei
Tao, Xiao-Mei
Song, Chun-Li
Item Type: 
Journal Article
Publication Title: 
Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Journal Abbreviation: 
Support Care Cancer
Publication Date: 
2017-07
Publication Year: 
2017
Pages: 
2335-2347
Volume: 
25
Issue: 
7
ISSN: 
1433-7339
DOI: 
10.1007/s00520-017-3691-y
Library Catalog: 
PubMed
Extra: 
PMID: 28397023

Turabian/Chicago Citation

Wei-Wei Tao, Xiao-Mei Tao and Chun-Li Song. 2017-07. "Effects of non-pharmacological supportive care for hot flushes in breast cancer: a meta-analysis." Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer 25: 7: 2335-2347. 10.1007/s00520-017-3691-y.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1007/s00520-017-3691-y | issn = 1433-7339 | volume = 25 | pages = 2335-2347 | last = Tao | first = Wei-Wei | coauthors = Tao, Xiao-Mei, Song, Chun-Li | title = Effects of non-pharmacological supportive care for hot flushes in breast cancer: a meta-analysis | journal = Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer | date = 2017-07 | pmid = | pmc = }} </ref>