Effects of penta-O-galloyl-?-D-glucose on human neutrophil function: significant down-regulation of L-selectin expression
Language: 
English
Short Title: 
Effects of penta-O-galloyl-?-D-glucose on human neutrophil function
Abstract: 

Penta-O-galloyl-?-D-glucose (PGG) occurrs in high concentrations in medicinal herbs such as Rhus chinensis, Paeonia suffruticosa, Acer truncatum and Terminalia chebula, which demonstrate anti-inflammatory activity. We investigated the effect of PGG on stimulated and non-stimulated neutrophils in processes which included reactive oxygen species generation (ROS), metalloproteinase-9 and interleukin-8 secretion (IL-8), ?? integrin (CD11b) and L-selectin (CD62L) expression and apoptosis. In concentrations of 5??M-20??M, PGG demonstrated statistically significant inhibition of ROS generation, IL-8 secretion and ?? integrin expression in stimulated neutrophils. The inhibition of L-selectin expression by PGG resulted in prevention in neutrophils' endothelial attachment. The result obtained may explain the anti-inflammatory activity of this compound and underline the contribution of PGG in the activity of PGG rich plant extracts.

Author(s): 
Kiss, Anna K.
Filipek, Agnieszka
Zy?y?ska-Granica, Barbara
Naruszewicz, Marek
Item Type: 
Journal Article
Publication Title: 
Phytotherapy research: PTR
Journal Abbreviation: 
Phytother Res
Publication Date: 
2013-07
Publication Year: 
2013
Pages: 
986-992
Volume: 
27
Issue: 
7
ISSN: 
1099-1573
DOI: 
10.1002/ptr.4822
Library Catalog: 
PubMed
Extra: 
PMID: 22899541

Turabian/Chicago Citation

Anna K. Kiss, Agnieszka Filipek, Barbara Zy?y?ska-Granica and Marek Naruszewicz. 2013-07. "Effects of penta-O-galloyl-?-D-glucose on human neutrophil function: significant down-regulation of L-selectin expression." Phytotherapy research: PTR 27: 7: 986-992. 10.1002/ptr.4822.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1002/ptr.4822 | issn = 1099-1573 | volume = 27 | pages = 986-992 | last = Kiss | first = Anna K. | coauthors = Filipek, Agnieszka, Zy?y?ska-Granica, Barbara, Naruszewicz, Marek | title = Effects of penta-O-galloyl-?-D-glucose on human neutrophil function: significant down-regulation of L-selectin expression | journal = Phytotherapy research: PTR | date = 2013-07 | pmid = | pmc = }} </ref>