Efficacy of a mouthwash containing 0.8% arginine, PVM/MA copolymer, pyrophosphates, and 0.05% sodium fluoride compared to a commercial mouthwash containing 2.4% potassium nitrate and 0.022% sodium fluoride and a control mouthwash containing 0.05% sodium fluoride on dentine hypersensitivity: a six-week randomized clinical study
Language: 
English
Short Title: 
Efficacy of a mouthwash containing 0.8% arginine, PVM/MA copolymer, pyrophosphates, and 0.05% sodium fluoride compared to a commercial mouthwash containing 2.4% potassium nitrate and 0.022% sodium fluoride and a control mouthwash containing 0.05% sodium fluoride on dentine hypersensitivity
Abstract: 

OBJECTIVE: Evaluate the efficacy of 0.8% arginine, potassium nitrate and sodium fluoride mouthwashes on dentine hypersensitivity reduction. METHODS: Six week randomized, double blinded, two cell, parallel single centre clinical study in the Dominican Republic; subjects were randomized into three treatment groups: mouthwash containing 0.8% arginine, PVM/MA copolymer, pyrophosphates, and 0.05% sodium fluoride in an alcohol-free base (arginine); mouthwash containing 2.4% potassium nitrate and 0.022% sodium fluoride (potassium nitrate); a control mouthwash containing 0.05% sodium fluoride (negative control). Tactile and air-blast dentine hypersensitivity assessments were conducted at baseline, thirty minutes post rinsing and two, four, and six weeks of twice-daily product use. For treatment group comparisons, ANCOVA and post hoc Tukey's pair-wise comparisons (α=0.05) were done. RESULTS: Seventy-five subjects were enrolled; 69 subjects completed the study. There were no differences after thirty minutes of a single use, among the three groups with respect to mean tactile and air blast hypersensitivity scores compared to potassium nitrate and negative control mouthwashes (p<0.05). The arginine group presented a statistically significant improvement in the mean tactile scores compared to potassium nitrate and negative control groups after two, four, and six weeks (p<0.001) of product use; the arginine group showed a statistically significant enhancement in air blast hypersensitivity mean scores compared to potassium nitrate and negative control groups after two (p=0.001), four (p<0.001), and six weeks (p<0.001) of product use. CONCLUSION: A mouthwash containing arginine provides a significant and superior reduction in dentine hypersensitivity compared to potassium nitrate and a negative control mouthwash after two weeks.

Author(s): 
Elias Boneta, Augusto R.
Galán Salás, Rafael M.
Mateo, Luis R.
Stewart, Bernal
Mello, Sarita
Arvanitidou, Lia S.
Panagakos, Foti
DeVizio, William
Item Type: 
Journal Article
Publication Title: 
Journal of Dentistry
Journal Abbreviation: 
J Dent
Publication Date: 
Mar 2013
Publication Year: 
2013
Pages: 
S34-41
Volume: 
41 Suppl 1
ISSN: 
1879-176X
DOI: 
10.1016/j.jdent.2012.11.004
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 23380074

Turabian/Chicago Citation

Augusto R. Elias Boneta, Rafael M. Galán Salás, Luis R. Mateo, Bernal Stewart, Sarita Mello, Lia S. Arvanitidou, Foti Panagakos and William DeVizio. Mar 2013. "Efficacy of a mouthwash containing 0.8% arginine, PVM/MA copolymer, pyrophosphates, and 0.05% sodium fluoride compared to a commercial mouthwash containing 2.4% potassium nitrate and 0.022% sodium fluoride and a control mouthwash containing 0.05% sodium fluoride on dentine hypersensitivity: a six-week randomized clinical study." Journal of Dentistry 41 Suppl 1: S34-41. 10.1016/j.jdent.2012.11.004.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.jdent.2012.11.004 | issn = 1879-176X | volume = 41 Suppl 1 | pages = S34-41 | last = Elias Boneta | first = Augusto R. | coauthors = Galán Salás, Rafael M., Mateo, Luis R., Stewart, Bernal, Mello, Sarita, Arvanitidou, Lia S., Panagakos, Foti, DeVizio, William | title = Efficacy of a mouthwash containing 0.8% arginine, PVM/MA copolymer, pyrophosphates, and 0.05% sodium fluoride compared to a commercial mouthwash containing 2.4% potassium nitrate and 0.022% sodium fluoride and a control mouthwash containing 0.05% sodium fluoride on dentine hypersensitivity: a six-week randomized clinical study | journal = Journal of Dentistry | date = Mar 2013 | pmid = | pmc = }} </ref>