Efficacy of a mouthwash containing 0.8% arginine, PVM/MA copolymer, pyrophosphates, and 0.05% sodium fluoride compared to a negative control mouthwash on dentin hypersensitivity reduction. A randomized clinical trial
Language: 
English
Abstract: 

OBJECTIVE: The objective of this eight week, single-center, two-cell, double-blind, and randomized clinical study was to evaluate the dentin hypersensitivity reduction efficacy of a mouthwash using Pro-Argin™ Mouthwash Technology containing 0.8% arginine, PVM/MA copolymer, pyrophosphates, and 0.05% sodium fluoride in an alcohol-free base ("Arginine Mouthwash") compared to an ordinary mouthwash without any active ingredients ("Negative Control"). METHODS: Qualifying subjects who presented two hypersensitive teeth with a tactile hypersensitivity score between 10 and 50 g of force, and an air blast hypersensitivity score of 2 or 3 participated in this study and were randomized into one of two treatment groups. Subjects brushed with the toothbrush and fluoride toothpaste provided and then rinsed with 20 mL of their assigned mouthwash for 30s twice daily. Subjects refrained from eating or drinking for 30 min after rinsing. Dentin hypersensitivity assessments, as well as examinations of oral hard and soft tissues, were conducted at the baseline visit and again after two weeks, four weeks and eight weeks of product use. RESULTS: Ninety (90) subjects entered and completed the eight week study. After two weeks, four weeks and eight weeks of product use, subjects in the Arginine Mouthwash group exhibited statistically significant (p<0.05) improvements in mean tactile and air blast hypersensitivity scores as compared to the Negative Control Mouthwash. CONCLUSION: The results of this study support the conclusion that the Arginine Mouthwash provides a significant reduction in dentin hypersensitivity after eight weeks of product use as compared to a Negative Control mouthwash.

Author(s): 
Hu, Deyu
Stewart, Bernal
Mello, Sarita
Arvanitidou, Lia
Panagakos, Foti
De Vizio, William
Zhang, Yun Po
Mateo, Luis R.
Yin, Wei
Item Type: 
Journal Article
Publication Title: 
Journal of Dentistry
Journal Abbreviation: 
J Dent
Publication Date: 
Mar 2013
Publication Year: 
2013
Pages: 
S26-33
Volume: 
41 Suppl 1
ISSN: 
1879-176X
DOI: 
10.1016/j.jdent.2012.10.001
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 23380072

Turabian/Chicago Citation

Deyu Hu, Bernal Stewart, Sarita Mello, Lia Arvanitidou, Foti Panagakos, William De Vizio, Yun Po Zhang, Luis R. Mateo and Wei Yin. Mar 2013. "Efficacy of a mouthwash containing 0.8% arginine, PVM/MA copolymer, pyrophosphates, and 0.05% sodium fluoride compared to a negative control mouthwash on dentin hypersensitivity reduction. A randomized clinical trial." Journal of Dentistry 41 Suppl 1: S26-33. 10.1016/j.jdent.2012.10.001.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.jdent.2012.10.001 | issn = 1879-176X | volume = 41 Suppl 1 | pages = S26-33 | last = Hu | first = Deyu | coauthors = Stewart, Bernal, Mello, Sarita, Arvanitidou, Lia, Panagakos, Foti, De Vizio, William, Zhang, Yun Po, Mateo, Luis R., Yin, Wei | title = Efficacy of a mouthwash containing 0.8% arginine, PVM/MA copolymer, pyrophosphates, and 0.05% sodium fluoride compared to a negative control mouthwash on dentin hypersensitivity reduction. A randomized clinical trial | journal = Journal of Dentistry | date = Mar 2013 | pmid = | pmc = }} </ref>