Efficacy in reducing dentine hypersensitivity of a regimen using a toothpaste containing 8% arginine and calcium carbonate, a mouthwash containing 0.8% arginine, pyrophosphate and PVM/MA copolymer and a toothbrush compared to potassium and negative control regimens: an eight-week randomized clinical trial
Language: 
English
Short Title: 
Efficacy in reducing dentine hypersensitivity of a regimen using a toothpaste containing 8% arginine and calcium carbonate, a mouthwash containing 0.8% arginine, pyrophosphate and PVM/MA copolymer and a toothbrush compared to potassium and negative control regimens
Abstract: 

OBJECTIVE: Evaluate the efficacy of three regimens integrating toothpaste, toothbrush and mouthwash in reducing dentine hypersensitivity. METHODS: Eight-week single-centre, three-cell, double-blind, randomized study was conducted in the Dominican Republic. Subjects entered one of the three regimens: (1) toothpaste containing 8% arginine and 1450 ppm mono-fluorophosphate, in a calcium carbonate base, a soft-bristle toothbrush followed by a mouthwash containing 0.8% arginine, PVM/MA copolymer, pyrophosphates, and 0.05% sodium fluoride; (2) toothpaste containing 5% potassium nitrate and 1450 ppm sodium fluoride, a soft-bristle toothbrush, followed by a mouthwash containing 0.51% potassium chloride and 230 ppm sodium fluoride; and (3) toothpaste containing 1450 ppm mono-fluorophosphate, a soft-bristle toothbrush followed by a fluoride/arginine free mouthwash. Tactile and Air-Blast dentine hypersensitivity measurements were performed at baseline, two, four, and eight weeks. For treatment group comparisons, ANCOVA and post hoc Tukey's pair-wise (α=0.05) were used. Kaplan-Meier survival analysis was performed to evaluate Time to Treatment Improvement. RESULTS: 120 subjects were enrolled, 118 completed the study. The Tactile hypersensitivity mean scores showed statistically significant improvement at two, four and eight (p ≤ 0.001) weeks in the arginine regime; the potassium regime did not show significant (p ≥ 0.05) improvement. Air-Blast Hypersensitivity scores had a statistically significant decrease at two (p=0.006), four (p=0.006) and eight (p=0.002) weeks in arginine and potassium regimes (p ≤ 0.05). The most effective treatment proved to be arginine (p ≤ 0.05) compared to the potassium regime. CONCLUSION: Arginine regimen provided the greatest reduction in Tactile and Air-Blast dentine hypersensitivity compared to potassium and negative control regimens; and provides faster dentine hypersensitivity relief than potassium regimen.

Author(s): 
Elias Boneta, Augusto R.
Ramirez, Karol
Naboa, Joselyn
Mateo, Luis R.
Stewart, Bernal
Panagokos, Foti
De Vizio, William
Item Type: 
Journal Article
Publication Title: 
Journal of Dentistry
Journal Abbreviation: 
J Dent
Publication Date: 
Mar 2013
Publication Year: 
2013
Pages: 
S42-49
Volume: 
41 Suppl 1
ISSN: 
1879-176X
DOI: 
10.1016/j.jdent.2012.11.011
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 23380274

Turabian/Chicago Citation

Augusto R. Elias Boneta, Karol Ramirez, Joselyn Naboa, Luis R. Mateo, Bernal Stewart, Foti Panagokos and William De Vizio. Mar 2013. "Efficacy in reducing dentine hypersensitivity of a regimen using a toothpaste containing 8% arginine and calcium carbonate, a mouthwash containing 0.8% arginine, pyrophosphate and PVM/MA copolymer and a toothbrush compared to potassium and negative control regimens: an eight-week randomized clinical trial." Journal of Dentistry 41 Suppl 1: S42-49. 10.1016/j.jdent.2012.11.011.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.jdent.2012.11.011 | issn = 1879-176X | volume = 41 Suppl 1 | pages = S42-49 | last = Elias Boneta | first = Augusto R. | coauthors = Ramirez, Karol, Naboa, Joselyn, Mateo, Luis R., Stewart, Bernal, Panagokos, Foti, De Vizio, William | title = Efficacy in reducing dentine hypersensitivity of a regimen using a toothpaste containing 8% arginine and calcium carbonate, a mouthwash containing 0.8% arginine, pyrophosphate and PVM/MA copolymer and a toothbrush compared to potassium and negative control regimens: an eight-week randomized clinical trial | journal = Journal of Dentistry | date = Mar 2013 | pmid = | pmc = }} </ref>