Efficacy of traditional herbal medicines in combination with acyclovir against herpes simplex virus type 1 infection in vitro and in vivo
Language: 
English
Abstract: 

Traditional herbal medicines have been safely used for the treatment of various human diseases since ancient China. We selected 10 herbal extracts with therapeutic antiherpes simplex virus type 1 (HSV-1) activity. Among these, Geum japonicum Thunb., Rhus javanica L., Syzygium aromaticum (L.) Merr. et Perry, or Terminalia chebula Retzus showed a stronger anti-HSV-1 activity in combination with acyclovir than the other herbal extracts in vitro. When acyclovir and/or a herbal extract were orally administered at doses corresponding to human use, each of the 4 combinations significantly limited the development of skin lesions and/or prolonged the mean survival times of infected mice compared with both acyclovir and the herbal extract alone (P < 0.01 or 0.05). These combinations were not toxic to mice. They reduced virus yields in the brain and skin more strongly than acyclovir alone and exhibited stronger anti-HSV-1 activity in the brain than in the skin, in contrast to acyclovir treatment by itself. Combinations of acyclovir with historically used herbal medicines showed strong combined therapeutic anti-HSV-1 activity in mice, especially reduction of virus yield in the brain.

Author(s): 
Kurokawa, M.
Nagasaka, K.
Hirabayashi, T.
Uyama, S.
Sato, H.
Kageyama, T.
Kadota, S.
Ohyama, H.
Hozumi, T.
Namba, T.
Item Type: 
Journal Article
Publication Title: 
Antiviral Research
Journal Abbreviation: 
Antiviral Res.
Publication Date: 
1995-05
Publication Year: 
1995
Pages: 
19-37
Volume: 
27
Issue: 
2-Jan
ISSN: 
0166-3542
Library Catalog: 
PubMed
Extra: 
PMID: 7486956

Turabian/Chicago Citation

M. Kurokawa, K. Nagasaka, T. Hirabayashi, S. Uyama, H. Sato, T. Kageyama, S. Kadota, H. Ohyama, T. Hozumi and T. Namba. 1995-05. "Efficacy of traditional herbal medicines in combination with acyclovir against herpes simplex virus type 1 infection in vitro and in vivo." Antiviral Research 27: 2-Jan: 19-37.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 0166-3542 | volume = 27 | pages = 19-37 | last = Kurokawa | first = M. | coauthors = Nagasaka, K., Hirabayashi, T., Uyama, S., Sato, H., Kageyama, T., Kadota, S., Ohyama, H., Hozumi, T., Namba, T. | title = Efficacy of traditional herbal medicines in combination with acyclovir against herpes simplex virus type 1 infection in vitro and in vivo | journal = Antiviral Research | date = 1995-05 | pmid = | pmc = }} </ref>