EGFR inhibitor erlotinib delays disease progression but does not extend survival in the SOD1 mouse model of ALS
Language: 
English
Abstract: 

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that causes progressive paralysis due to motor neuron death. Several lines of published evidence suggested that inhibition of epidermal growth factor receptor (EGFR) signaling might protect neurons from degeneration. To test this hypothesis in vivo, we treated the SOD1 transgenic mouse model of ALS with erlotinib, an EGFR inhibitor clinically approved for oncology indications. Although erlotinib failed to extend ALS mouse survival it did provide a modest but significant delay in the onset of multiple behavioral measures of disease progression. However, given the lack of protection of motor neuron synapses and the lack of survival extension, the small benefits observed after erlotinib treatment appear purely symptomatic, with no modification of disease course.

Author(s): 
Le Pichon, Claire E.
Dominguez, Sara L.
Solanoy, Hilda
Ngu, Hai
Lewin-Koh, Nicholas
Chen, Mark
Eastham-Anderson, Jeffrey
Watts, Ryan
Scearce-Levie, Kimberly
Item Type: 
Journal Article
Publication Title: 
PloS One
Journal Abbreviation: 
PLoS ONE
Publication Date: 
2013
Publication Year: 
2013
Pages: 
e62342
Volume: 
8
Issue: 
4
ISSN: 
1932-6203
DOI: 
10.1371/journal.pone.0062342
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 23638043 PMCID: PMC3637182

Turabian/Chicago Citation

Claire E. Le Pichon, Sara L. Dominguez, Hilda Solanoy, Hai Ngu, Nicholas Lewin-Koh, Mark Chen, Jeffrey Eastham-Anderson, Ryan Watts and Kimberly Scearce-Levie. 2013. "EGFR inhibitor erlotinib delays disease progression but does not extend survival in the SOD1 mouse model of ALS." PloS One 8: 4: e62342. 10.1371/journal.pone.0062342.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1371/journal.pone.0062342 | issn = 1932-6203 | volume = 8 | pages = e62342 | last = Le Pichon | first = Claire E. | coauthors = Dominguez, Sara L., Solanoy, Hilda, Ngu, Hai, Lewin-Koh, Nicholas, Chen, Mark, Eastham-Anderson, Jeffrey, Watts, Ryan, Scearce-Levie, Kimberly | title = EGFR inhibitor erlotinib delays disease progression but does not extend survival in the SOD1 mouse model of ALS | journal = PloS One | date = 2013 | pmid = | pmc = }} </ref>