Electroacupuncture improves impaired gastric motility and slow waves induced by rectal distension in dogs
Language: 
English
Abstract: 

Rectal distension (RD) is known to induce upper gastrointestinal (GI) symptoms. The aim of this study was to investigate the effects and underlying mechanisms of RD on gastric slow waves (GSW) and motor activity and furthermore to investigate the effects and mechanisms of electroacupuncture (EA) on GSW and motor activity. Eight female hound dogs chronically implanted with gastric serosal electrodes and a gastric fistula were studied in six separate sessions. Antral motility, GSW, heart rate variability, and rectal pressure were evaluated for the above purposes. 1) RD at a volume of 120 ml suppressed antral motility significantly. Guanethidine blocked the inhibitory effect of RD. EA at ST36 was able to restore the suppressed antral contractions induced by RD (16.6+/-1.7 vs. 8.0+/-1.4, P<0.001). Naloxone partially blocked the effect of EA on antral contractions. 2) RD reduced the percentage of normal GSW from 98.8+/-0.8% at baseline to 76.1+/-8.6% (P<0.05) that was increased to 91.8+/-3.0% with EA. The effects of EA on the GSW were nullified by the presence of naloxone. 3) EA did not show any significant effect on rectal pressure, suggesting that the ameliorating effects of EA on RD-induced impaired gastric motility were not due to a decrease in rectal pressure. 4) EA increased the vagal activity suppressed by RD. In conclusion, RD inhibits postprandial gastric motility and impairs GSW in dogs, and the inhibitory effects are mediated via the adrenergic pathways. EA at ST36 is able to restore the RD-induced impaired GSW and motor activities, possibly by enhancing vagal activity, and is partially mediated via the opioid pathway. EA may have therapeutic potential for functional gastrointestinal disorders.

Author(s): 
Chen, Jie
Song, Geng-Qing
Yin, Jieyun
Koothan, Thillai
Chen, J. D. Z.
Item Type: 
Journal Article
Publication Title: 
American Journal of Physiology. Gastrointestinal and Liver Physiology
Journal Abbreviation: 
Am. J. Physiol. Gastrointest. Liver Physiol.
Publication Date: 
Sep 2008
Publication Year: 
2008
Pages: 
G614-620
Volume: 
295
Issue: 
3
ISSN: 
0193-1857
DOI: 
10.1152/ajpgi.90322.2008
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 18653722

Turabian/Chicago Citation

Jie Chen, Geng-Qing Song, Jieyun Yin, Thillai Koothan and J. D. Z. Chen. Sep 2008. "Electroacupuncture improves impaired gastric motility and slow waves induced by rectal distension in dogs." American Journal of Physiology. Gastrointestinal and Liver Physiology 295: 3: G614-620. 10.1152/ajpgi.90322.2008.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1152/ajpgi.90322.2008 | issn = 0193-1857 | volume = 295 | pages = G614-620 | last = Chen | first = Jie | coauthors = Song, Geng-Qing, Yin, Jieyun, Koothan, Thillai, Chen, J. D. Z. | title = Electroacupuncture improves impaired gastric motility and slow waves induced by rectal distension in dogs | journal = American Journal of Physiology. Gastrointestinal and Liver Physiology | date = Sep 2008 | pmid = | pmc = }} </ref>