Electroencephalographic study of the short-acting hypnotics etomidate and methohexital in dogs
Language: 
English
Abstract: 

Beagles, implanted with cortical and subcortical electrodes, were given etomidate i.v. (1 mg/kg) over a period of 10 sec. The effects on the EEG were compared with those obtained with 7 mg/kg of methohexital. Both compounds induced hypnosis for a duration of approximately 8 min. The EEGs showed a remarkable similarity. Visual inspection of the records as well as power spectrum analysis revealed a sustained theta-activity with underlying fast activity. The configuration of the waves was rather sharp. The power obtained after etomidate was, however, 2 to 3 times that obtained after methohexital. When the animals awoke from etomidate-induced hypnosis slow waves appeared and were followed by alpha-activity, whereas after methohexital-hypnosis beta-activity predominated. Etomidate slightly increased heart rate, but respiratory depression was not observed. Methohexital caused pronounced tachycardia and apnoea. In 3 out of 6 dogs methohexital caused myoclonus of the hind legs upon awakening from anaesthesia. Etomidate induced myoclonus in one dog during hypnosis.

Author(s): 
Wauquier, A.
van den Broeck, W. A.
Verheyen, J. L.
Janssen, P. A.
Item Type: 
Journal Article
Publication Title: 
European Journal of Pharmacology
Journal Abbreviation: 
Eur. J. Pharmacol.
Publication Date: 
2/15/1978
Publication Year: 
1978
Pages: 
367-377
Volume: 
47
Issue: 
4
ISSN: 
0014-2999
Library Catalog: 
PubMed
Extra: 
PMID: 631187

Turabian/Chicago Citation

A. Wauquier, W. A. van den Broeck, J. L. Verheyen and P. A. Janssen. 2/15/1978. "Electroencephalographic study of the short-acting hypnotics etomidate and methohexital in dogs." European Journal of Pharmacology 47: 4: 367-377.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 0014-2999 | volume = 47 | pages = 367-377 | last = Wauquier | first = A. | coauthors = van den Broeck, W. A., Verheyen, J. L., Janssen, P. A. | title = Electroencephalographic study of the short-acting hypnotics etomidate and methohexital in dogs | journal = European Journal of Pharmacology | date = 2/15/1978 | pmid = | pmc = }} </ref>