The emerging therapeutic potential of sirtuin-interacting drugs: from cell death to lifespan extension
Language: 
English
Short Title: 
The emerging therapeutic potential of sirtuin-interacting drugs
Abstract: 

Acetylation of chromatin-interacting proteins is central to the epigenetic regulation of genome architecture and gene expression. Chemicals that modulate the acetylation of nuclear proteins have proved instrumental in experimental models of several human diseases. Sirtuins represent a new class of evolutionary conserved histone deacetylases, originally identified in yeast, that have emerging pathogenetic roles in cancer, diabetes, muscle differentiation, heart failure, neurodegeneration and aging. In this article, we focus on sirtuins and provide an appraisal of current compounds that either activate or inhibit sirtuin activity, highlighting their therapeutic potential for the treatment of human diseases.

Author(s): 
Porcu, Marco
Chiarugi, Alberto
Item Type: 
Journal Article
Publication Title: 
Trends in Pharmacological Sciences
Journal Abbreviation: 
Trends Pharmacol. Sci.
Publication Date: 
2005-02
Publication Year: 
2005
Pages: 
94-103
Volume: 
26
Issue: 
2
ISSN: 
0165-6147
DOI: 
10.1016/j.tips.2004.12.009
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 15681027

Turabian/Chicago Citation

Marco Porcu and Alberto Chiarugi. 2005-02. "The emerging therapeutic potential of sirtuin-interacting drugs: from cell death to lifespan extension." Trends in Pharmacological Sciences 26: 2: 94-103. 10.1016/j.tips.2004.12.009.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.tips.2004.12.009 | issn = 0165-6147 | volume = 26 | pages = 94-103 | last = Porcu | first = Marco | coauthors = Chiarugi, Alberto | title = The emerging therapeutic potential of sirtuin-interacting drugs: from cell death to lifespan extension | journal = Trends in Pharmacological Sciences | date = 2005-02 | pmid = | pmc = }} </ref>