Energy restriction controls aging through neuroendocrine signal transduction
Language: 
English
Abstract: 

Since the work of McCay in 1935, demonstrating the effect of energy restricted diet on the lifespan of rats, many studies have confirmed these findings in different species. Several mechanisms have been suggested, including among others, growth retardation, diminished apoptosis, decreased oxidative damage, altered glucose utilization, changes in gene expression, enhanced stress responsiveness and hormesis. There is some evidence that energy restriction (ER) exerts important metabolic effects on the aging process and longevity through intra- and intercellular signal transduction transmitters, with several signaling pathways mediating its beneficial action.

Author(s): 
Berner, Yitshal N.
Stern, Felicia
Item Type: 
Journal Article
Publication Title: 
Ageing Research Reviews
Journal Abbreviation: 
Ageing Res. Rev.
Publication Date: 
2004-04
Publication Year: 
2004
Pages: 
189-198
Volume: 
3
Issue: 
2
ISSN: 
1568-1637
DOI: 
10.1016/j.arr.2003.10.004
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 15177054

Turabian/Chicago Citation

Yitshal N. Berner and Felicia Stern. 2004-04. "Energy restriction controls aging through neuroendocrine signal transduction." Ageing Research Reviews 3: 2: 189-198. 10.1016/j.arr.2003.10.004.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.arr.2003.10.004 | issn = 1568-1637 | volume = 3 | pages = 189-198 | last = Berner | first = Yitshal N. | coauthors = Stern, Felicia | title = Energy restriction controls aging through neuroendocrine signal transduction | journal = Ageing Research Reviews | date = 2004-04 | pmid = | pmc = }} </ref>