Enhancement of interleukin-2 production and its mRNA expression by dihydroartemisinin
Language: 
English
Abstract: 

Immunoregulatory properties of a novel antimalarial drug dihydroartemisinin (DHA) were investigated in vitro. DHA 0.5-5 mumol.L-1 enhanced the lymphocyte proliferation induced by Con A. Interleukin 2 (IL-2) production and its mRNA expression by both Con A-stimulated mouse splenocytes and a T cell line LBRM-33-1A5 were also augmented by DHA. In contrast, DHA 0.5-5 mumol.L-1 did not show any effect on the lipopolysaccharides (LPS)-induced lymphocyte proliferation and the spontaneous and mitogen-induced proliferation of transformed T cells. These results indicated that DHA might regulate lymphocyte responses through the induction of IL-2 production and that the enhanced T cell proliferation and IL-2 production might be mediated through different pathways.

Author(s): 
Yang, S. X.
Xie, S. S.
Ma, D. L.
Gao, H. L.
Long, Z. Z.
Item Type: 
Journal Article
Publication Title: 
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica
Journal Abbreviation: 
Zhongguo Yao Li Xue Bao
Publication Date: 
Nov-94
Publication Year: 
1994
Pages: 
515-520
Volume: 
15
Issue: 
6
ISSN: 
0253-9756
Library Catalog: 
PubMed
Extra: 
PMID: 7709750

Turabian/Chicago Citation

S. X. Yang, S. S. Xie, D. L. Ma, H. L. Gao and Z. Z. Long. Nov-94. "Enhancement of interleukin-2 production and its mRNA expression by dihydroartemisinin." Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica 15: 6: 515-520.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 0253-9756 | volume = 15 | pages = 515-520 | last = Yang | first = S. X. | coauthors = Xie, S. S., Ma, D. L., Gao, H. L., Long, Z. Z. | title = Enhancement of interleukin-2 production and its mRNA expression by dihydroartemisinin | journal = Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica | date = Nov-94 | pmid = | pmc = }} </ref>