Enhancement of systemic and sputum granulocyte response to inhaled endotoxin in people with the GSTM1 null genotype
Language: 
English
Abstract: 

OBJECTIVE: To determine if the GSTM1 null genotype is a risk factor for increased inflammatory response to inhaled endotoxin. METHODS: 35 volunteers who had undergone inhalation challenge with a 20 000 endotoxin unit dose of Clinical Center Reference Endotoxin (CCRE) were genotyped for the GSTM1 null polymorphism. Parameters of airway and systemic inflammation observed before and after challenge were compared in GSTM1 null (n=17) and GSTM1 (n=18) sufficient volunteers. RESULTS: GSTM1 null volunteers had significantly increased circulating white blood cells (WBCs), polymorphonuclear neutrophils (PMNs), platelets and sputum PMNs (% sputum PMNs and PMNs/mg sputum) after CCRE challenge. GSTM1 sufficient volunteers had significant, but lower increases in circulating WBCs, PMNs and % sputum PMNs, and no increase in platelets or PMNs/mg sputum. Linear regression analysis adjusted for baseline values of the entire cohort revealed that the GSTM1 null genotype significantly increased circulating WBCs, platelets and % sputum PMNs after challenge. CONCLUSION: These data support the hypothesis that the GSTM1 null genotype is a risk factor for increased acute respiratory and systemic inflammatory response to inhaled CCRE. These data are consistent with other observations that the GSTM1 null genotype is associated with increased respiratory, systemic and cardiovascular effects linked to ambient air particulate matter exposure and indicate that the GSTM1 null genotype should be considered a risk factor for adverse health effects associated with exposure to environmental endotoxin.

Author(s): 
Dillon, Madeline A.
Harris, Bradford
Hernandez, Michelle L.
Zou, Baiming
Reed, William
Bromberg, Philip A.
Devlin, Robert B.
Diaz-Sanchez, David
Kleeberger, Steven
Zhou, Haibo
Lay, John C.
Alexis, Neil E.
Peden, David B.
Item Type: 
Journal Article
Publication Title: 
Occupational and Environmental Medicine
Journal Abbreviation: 
Occup Environ Med
Publication Date: 
Oct 2011
Publication Year: 
2011
Pages: 
783-785
Volume: 
68
Issue: 
10
ISSN: 
1470-7926
DOI: 
10.1136/oem.2010.061747
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 21441173 PMCID: PMC3808962

Turabian/Chicago Citation

Madeline A. Dillon, Bradford Harris, Michelle L. Hernandez, Baiming Zou, William Reed, Philip A. Bromberg, Robert B. Devlin, David Diaz-Sanchez, Steven Kleeberger, Haibo Zhou, John C. Lay, Neil E. Alexis and David B. Peden. Oct 2011. "Enhancement of systemic and sputum granulocyte response to inhaled endotoxin in people with the GSTM1 null genotype." Occupational and Environmental Medicine 68: 10: 783-785. 10.1136/oem.2010.061747.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1136/oem.2010.061747 | issn = 1470-7926 | volume = 68 | pages = 783-785 | last = Dillon | first = Madeline A. | coauthors = Harris, Bradford, Hernandez, Michelle L., Zou, Baiming, Reed, William, Bromberg, Philip A., Devlin, Robert B., Diaz-Sanchez, David, Kleeberger, Steven, Zhou, Haibo, Lay, John C., Alexis, Neil E., Peden, David B. | title = Enhancement of systemic and sputum granulocyte response to inhaled endotoxin in people with the GSTM1 null genotype | journal = Occupational and Environmental Medicine | date = Oct 2011 | pmid = | pmc = }} </ref>