Enzymes of glycerol and glyceraldehyde metabolism in mouse liver: effects of caloric restriction and age on activities
Language: 
English
Short Title: 
Enzymes of glycerol and glyceraldehyde metabolism in mouse liver
Abstract: 

The influence of caloric restriction on hepatic glyceraldehyde- and glycerol-metabolizing enzyme activities of young and old mice were studied. Glycerol kinase and cytoplasmic glycerol-3-phosphate dehydrogenase activities were increased in both young and old CR (calorie-restricted) mice when compared with controls, whereas triokinase increased only in old CR mice. Aldehyde dehydrogenase and aldehyde reductase activities in both young and old CR mice were unchanged by caloric restriction. Mitochondrial glycerol-3-phosphate dehydrogenase showed a trend towards an increased activity in old CR mice, whereas a trend towards a decreased activity in alcohol dehydrogenase was observed in both young and old CR mice. Serum glycerol levels decreased in young and old CR mice. Therefore increases in glycerol kinase and glycerol-3-phosphate dehydrogenase were associated with a decrease in fasting blood glycerol levels in CR animals. A prominent role for triokinase in glyceraldehyde metabolism with CR was also observed. The results indicate that long-term caloric restriction induces sustained increases in the capacity for gluconeogenesis from glycerol.

Author(s): 
Hagopian, Kevork
Ramsey, Jon J.
Weindruch, Richard
Item Type: 
Journal Article
Publication Title: 
Bioscience Reports
Journal Abbreviation: 
Biosci. Rep.
Publication Date: 
Apr 2008
Publication Year: 
2008
Pages: 
107-115
Volume: 
28
Issue: 
2
ISSN: 
0144-8463
DOI: 
10.1042/BSR20080015
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 18429748 PMCID: PMC2538689

Turabian/Chicago Citation

Kevork Hagopian, Jon J. Ramsey and Richard Weindruch. Apr 2008. "Enzymes of glycerol and glyceraldehyde metabolism in mouse liver: effects of caloric restriction and age on activities." Bioscience Reports 28: 2: 107-115. 10.1042/BSR20080015.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1042/BSR20080015 | issn = 0144-8463 | volume = 28 | pages = 107-115 | last = Hagopian | first = Kevork | coauthors = Ramsey, Jon J., Weindruch, Richard | title = Enzymes of glycerol and glyceraldehyde metabolism in mouse liver: effects of caloric restriction and age on activities | journal = Bioscience Reports | date = Apr 2008 | pmid = | pmc = }} </ref>