Epidemiologic data on the relationships of caloric intake, energy balance, and weight gain over the life span with longevity and morbidity
Language: 
English
Abstract: 

Animal experiments have shown that calorically restricted (CR) animals weigh less and live longer than their ad libitum-fed peers. Are these observations applicable to human beings? This is an important question because the prevalence of obesity in America has increased markedly over recent years. We examine whether there are physiologic effects that occur with CR in humans that could plausibly explain the observed longevity of laboratory animals associated with CR. We also review epidemiologic data from observational and interventional studies on the relationships of caloric intake, energy balance, and weight gain with age-related diseases and longevity. Additionally, data on whether long-term, sustained maintenance of weight loss is feasible, as well as the degree of CR achieved in clinical trials, are summarized. Finally, we provide recommendations regarding further epidemiologic research that will help clarify unanswered questions in these areas.

Author(s): 
Lee, I. M.
Blair, S. N.
Allison, D. B.
Folsom, A. R.
Harris, T. B.
Manson, J. E.
Wing, R. R.
Item Type: 
Journal Article
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Journal Abbreviation: 
J. Gerontol. A Biol. Sci. Med. Sci.
Publication Date: 
2001-03
Publication Year: 
2001
Pages: 
19-Jul
Volume: 
56 Spec No 1
ISSN: 
1079-5006
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 12088215

Turabian/Chicago Citation

I. M. Lee, S. N. Blair, D. B. Allison, A. R. Folsom, T. B. Harris, J. E. Manson and R. R. Wing. 2001-03. "Epidemiologic data on the relationships of caloric intake, energy balance, and weight gain over the life span with longevity and morbidity." The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 56 Spec No 1: 19-Jul.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 1079-5006 | volume = 56 Spec No 1 | pages = 19-Jul | last = Lee | first = I. M. | coauthors = Blair, S. N., Allison, D. B., Folsom, A. R., Harris, T. B., Manson, J. E., Wing, R. R. | title = Epidemiologic data on the relationships of caloric intake, energy balance, and weight gain over the life span with longevity and morbidity | journal = The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences | date = 2001-03 | pmid = | pmc = }} </ref>