The epigenetic bottleneck of neurodegenerative and psychiatric diseases
Language: 
English
Abstract: 

The orchestrated expression of genes is essential for the development and survival of every organism. In addition to the role of transcription factors, the availability of genes for transcription is controlled by a series of proteins that regulate epigenetic chromatin remodeling. The two most studied epigenetic phenomena are DNA methylation and histone-tail modifications. Although a large body of literature implicates the deregulation of histone acetylation and DNA methylation with the pathogenesis of cancer, recently epigenetic mechanisms have also gained much attention in the neuroscientific community. In fact, a new field of research is rapidly emerging and there is now accumulating evidence that the molecular machinery that regulates histone acetylation and DNA methylation is intimately involved in synaptic plasticity and is essential for learning and memory. Importantly, dysfunction of epigenetic gene expression in the brain might be involved in neurodegenerative and psychiatric diseases. In particular, it was found that inhibition of histone deacetylases attenuates synaptic and neuronal loss in animal models for various neurodegenerative diseases and improves cognitive function. In this article, we will summarize recent data in the novel field of neuroepigenetics and discuss the question why epigenetic strategies are suitable therapeutic approaches for the treatment of brain diseases.

Author(s): 
Sananbenesi, Farahnaz
Fischer, Andre
Item Type: 
Journal Article
Publication Title: 
Biological Chemistry
Journal Abbreviation: 
Biol. Chem.
Publication Date: 
2009-11
Publication Year: 
2009
Pages: 
1145-1153
Volume: 
390
Issue: 
11
ISSN: 
1437-4315
DOI: 
10.1515/BC.2009.131
Library Catalog: 
PubMed
Extra: 
PMID: 19747081

Turabian/Chicago Citation

Farahnaz Sananbenesi and Andre Fischer. 2009-11. "The epigenetic bottleneck of neurodegenerative and psychiatric diseases." Biological Chemistry 390: 11: 1145-1153. 10.1515/BC.2009.131.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1515/BC.2009.131 | issn = 1437-4315 | volume = 390 | pages = 1145-1153 | last = Sananbenesi | first = Farahnaz | coauthors = Fischer, Andre | title = The epigenetic bottleneck of neurodegenerative and psychiatric diseases | journal = Biological Chemistry | date = 2009-11 | pmid = | pmc = }} </ref>