Epigenetic mechanisms expressed in basal ganglia GABAergic neurons differentiate schizophrenia from bipolar disorder
Language: 
English
Abstract: 

In the cerebral prefrontal cortex (PFC), DNA-methyltransferase 1 (DNMT1), the enzyme that catalyzes the methylation of cytosine at carbon atoms in position 5 in CpG dinucleotides, is expressed selectively in GABAergic neurons and is upregulated in layers I and II of schizophrenia (SZ) and bipolar disorder patients with psychosis (BDP). To replicate these earlier findings and to verify whether overexpression of DNMT1 and the consequent epigenetic decrease of reelin and glutamic acid decarboxylase (GAD) 67 mRNA expression also occur in GABAergic medium spiny neurons of the caudate nucleus (CN) and putamen (PT) of SZ and BDP, we studied the entire McLean 66 Cohort (Harvard Brain Tissue Resource Center, McLean Hospital, Belmont, MA) including SZ and BDP, which were matched with nonpsychiatric subjects. The data demonstrate that in GABAergic medium spiny neurons of CN and PT, unlike in GABAergic neurons of layer I and II PFC, the increased expression of DNMT1 and the decrease of reelin and GAD67 occur in SZ but not in BDP. This suggests that different epigenetic mechanisms must exist in the pathogenesis underlying SZ and BDP and implies that these disorders might involve two separate entities that are characterized by a well-defined neuropathology.

Author(s): 
Veldic, Marin
Kadriu, Bashkim
Maloku, Ekrem
Agis-Balboa, Roberto C.
Guidotti, Alessandro
Davis, John M.
Costa, Erminio
Item Type: 
Journal Article
Publication Title: 
Schizophrenia Research
Journal Abbreviation: 
Schizophr. Res.
Publication Date: 
2007-03
Publication Year: 
2007
Pages: 
51-61
Volume: 
91
Issue: 
3-Jan
ISSN: 
0920-9964
DOI: 
10.1016/j.schres.2006.11.029
Library Catalog: 
PubMed
Extra: 
PMID: 17270400 PMCID: PMC1876737

Turabian/Chicago Citation

Marin Veldic, Bashkim Kadriu, Ekrem Maloku, Roberto C. Agis-Balboa, Alessandro Guidotti, John M. Davis and Erminio Costa. 2007-03. "Epigenetic mechanisms expressed in basal ganglia GABAergic neurons differentiate schizophrenia from bipolar disorder." Schizophrenia Research 91: 3-Jan: 51-61. 10.1016/j.schres.2006.11.029.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.schres.2006.11.029 | issn = 0920-9964 | volume = 91 | pages = 51-61 | last = Veldic | first = Marin | coauthors = Kadriu, Bashkim, Maloku, Ekrem, Agis-Balboa, Roberto C., Guidotti, Alessandro, Davis, John M., Costa, Erminio | title = Epigenetic mechanisms expressed in basal ganglia GABAergic neurons differentiate schizophrenia from bipolar disorder | journal = Schizophrenia Research | date = 2007-03 | pmid = | pmc = }} </ref>