Evaluation of bronchodilator and anti-anaphylactic activity of Myrica sapida

BACKGROUND: Asthma is a chronic inflammatory disorder of the airways. The available treatment options have major limitations owing to low efficacy, associated adverse events and compliance issues. Therefore, the health burden of bronchial asthma is increasing globally at an alarming rate, providing a strong impetus for the development of new therapeutics. Myrica sapida is known traditionally in Ayurveda to possess anti-asthmatic activity. Hence, the present investigation was undertaken to evaluate the bronchodilator and anti-anaphylactic activity of the stem bark of Myrica sapida. METHODS: Experimental models studied were acetylcholine induced bronchospasm in guinea pigs, egg albumin induced anaphylaxis in guinea pigs, in vitro studies on tracheal strip of egg albumin sensitized guinea pigs. RESULTS: Treatment with ethanolic extract of M. sapida, 75 mg/kg, orally resulted in significant protection against acetylcholine aerosol induced bronchospasm and allergen induced anaphylaxis in guinea pigs. Ethanolic extract of M. sapida (75 mg/kg, p.o.) prevented the potentiation of responses and also produced a decrease in pD2 value of histamine and acetylcholine in guinea pig tracheal strip. CONCLUSION: These results suggest that M. sapida possesses bronchodilator activity, has potent inhibitory effect on immediate hyper-sensitivity reactions and decreases bronchial hyper-responsiveness.

Patel, Kalpana G.
Bhalodia, Payal N.
Patel, Ankita D.
Patel, Kirti V.
Gandhi, Tejal R.
Item Type: 
Journal Article
Publication Title: 
Iranian Biomedical Journal
Journal Abbreviation: 
Iran. Biomed. J.
Publication Date: 
Jul 2008
Publication Year: 
Library Catalog: 
NCBI Published Medical (?)
PMID: 18762824

Turabian/Chicago Citation

Kalpana G. Patel, Payal N. Bhalodia, Ankita D. Patel, Kirti V. Patel and Tejal R. Gandhi. Jul 2008. "Evaluation of bronchodilator and anti-anaphylactic activity of Myrica sapida." Iranian Biomedical Journal 12: 3: 191-196.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 1028-852X | volume = 12 | pages = 191-196 | last = Patel | first = Kalpana G. | coauthors = Bhalodia, Payal N., Patel, Ankita D., Patel, Kirti V., Gandhi, Tejal R. | title = Evaluation of bronchodilator and anti-anaphylactic activity of Myrica sapida | journal = Iranian Biomedical Journal | date = Jul 2008 | pmid = | pmc = }} </ref>