Evidence-based veterinary dermatology: a systematic review of the pharmacotherapy of canine atopic dermatitis
Language: 
English
Short Title: 
Evidence-based veterinary dermatology
Abstract: 

The efficacy of pharmacological interventions used to treat canine atopic dermatitis, excluding fatty acid supplementation and allergen-specific immunotherapy, was evaluated based on the systematic review of prospective clinical trials published between 1980 and 2002. Studies were compared with regard to design characteristics (randomization generation and concealment, masking, intention-to-treat analyses and quality of enrolment of study subjects), benefit (improvement in skin lesions or pruritus scores) and harm (type, severity and frequency of adverse drug events) of the various interventions. Meta-analysis of pooled results was not possible because of heterogeneity of the drugs evaluated. Forty trials enrolling 1607 dogs were identified. There is good evidence for recommending the use of oral glucocorticoids and cyclosporin for the treatment of canine atopic dermatitis, and fair evidence for using topical triamcinolone spray, topical tacrolimus lotion, oral pentoxifylline or oral misoprostol. Insufficient evidence is available for or against recommending the prescription of oral first- and second-generation type-1 histamine receptor antagonists, tricyclic antidepressants, cyproheptadine, aspirin, Chinese herbal therapy, an homeopathic complex remedy, ascorbic acid, AHR-13268, papaverine, immune-modulating antibiotics or tranilast and topical pramoxine or capsaicin. Finally, there is fair evidence against recommending the use of oral arofylline, leukotriene synthesis inhibitors and cysteinyl leukotriene receptor antagonists.

Author(s): 
Olivry, T.
Mueller, R. S.
International Task Force on Canine Atopic Dermatitis
Item Type: 
Journal Article
Publication Title: 
Veterinary Dermatology
Journal Abbreviation: 
Vet. Dermatol.
Publication Date: 
2003-06
Publication Year: 
2003
Pages: 
121-146
Volume: 
14
Issue: 
3
ISSN: 
0959-4493
Library Catalog: 
PubMed
Extra: 
PMID: 12791047

Turabian/Chicago Citation

T. Olivry, R. S. Mueller and International Task Force on Canine Atopic Dermatitis. 2003-06. "Evidence-based veterinary dermatology: a systematic review of the pharmacotherapy of canine atopic dermatitis." Veterinary Dermatology 14: 3: 121-146.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 0959-4493 | volume = 14 | pages = 121-146 | last = Olivry | first = T. | coauthors = Mueller, R. S., International Task Force on Canine Atopic Dermatitis | title = Evidence-based veterinary dermatology: a systematic review of the pharmacotherapy of canine atopic dermatitis | journal = Veterinary Dermatology | date = 2003-06 | pmid = | pmc = }} </ref>