Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study
Language: 
English
Short Title: 
Evidence of genetic enrichment for exceptional survival using a family approach
Abstract: 

We conducted a sib pair study in very old subjects for the purpose of mapping longevity loci. In the present analysis, we explore whether our recruitment strategy has resulted in a population enriched for a heritable component for exceptional longevity. Our study includes families with at least two long-living siblings (men aged 89 years or above; women aged 91 years or above). Data were collected on date of birth and, if applicable, date of death of parents, brothers and sisters, offspring, and spouses of the long-living participants. Standardised mortality ratios (SMRs) compared with the general Dutch population, were calculated. The SMR for all siblings of the long-living participants was 0.66 (95% CI 0.60-0.73). A similar survival benefit was also observed in the parents (SMR=0.76, 95% CI 0.66-0.87) and in the offspring of the long-living subjects (SMR=0.65, 95% CI 0.51-0.80). The SMR of the spouses of the long-living subjects was 0.95 (95% CI 0.82-1.12). The familial clustering of extended survival is unlikely to be caused by ascertainment bias, because in all analyses the long-living participants were excluded. Moreover, it is also unlikely to be caused by environmental factors, because the spouses of the long-living participants had a mortality risk comparable with the general Dutch population, whereas they share the same environment. We conclude that our sample is genetically enriched for extreme survival.

Author(s): 
Schoenmaker, Manja
de Craen, Anton J. M.
de Meijer, Paul H. E. M.
Beekman, Marian
Blauw, Gerard J.
Slagboom, P. Eline
Westendorp, Rudi G. J.
Item Type: 
Journal Article
Publication Title: 
European journal of human genetics: EJHG
Journal Abbreviation: 
Eur. J. Hum. Genet.
Publication Date: 
2006-01
Publication Year: 
2006
Pages: 
79-84
Volume: 
14
Issue: 
1
ISSN: 
1018-4813
DOI: 
10.1038/sj.ejhg.5201508
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 16251894

Turabian/Chicago Citation

Manja Schoenmaker, Anton J. M. de Craen, Paul H. E. M. de Meijer, Marian Beekman, Gerard J. Blauw, P. Eline Slagboom and Rudi G. J. Westendorp. 2006-01. "Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study." European journal of human genetics: EJHG 14: 1: 79-84. 10.1038/sj.ejhg.5201508.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1038/sj.ejhg.5201508 | issn = 1018-4813 | volume = 14 | pages = 79-84 | last = Schoenmaker | first = Manja | coauthors = de Craen, Anton J. M., de Meijer, Paul H. E. M., Beekman, Marian, Blauw, Gerard J., Slagboom, P. Eline, Westendorp, Rudi G. J. | title = Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study | journal = European journal of human genetics: EJHG | date = 2006-01 | pmid = | pmc = }} </ref>