Exceptional cellular resistance to oxidative damage in long-lived birds requires active gene expression
Language: 
English
Abstract: 

Previous studies indicated that renal tubular epithelial cells from some long-lived avian species exhibit robust and/or unique protective mechanisms against oxidative stress relative to murine cells. Here we extend these studies to investigate the response of primary embryonic fibroblast-like cells to oxidative challenge in long- and short-lived avian species (budgerigar, Melopsittacus undulatus, longevity up to 20 years, vs Japanese quail, Coturnix coturnix japonica, longevity up to 5 years) and short- and long-lived mammalian species (house mouse, Mus musculus, longevity up to 4 years vs humans, Homo sapiens, longevity up to 122 years). Under the conditions of our assay, the oxidative-damage resistance phenotype appears to be associated with exceptional longevity in avian species, but not in mammals. Furthermore, the extreme oxidative damage resistance phenotype observed in a long-lived bird requires active gene transcription and translation, suggesting that specific gene products may have evolved in long-lived birds to facilitate resistance to oxidative stress.

Author(s): 
Ogburn, C. E.
Carlberg, K.
Ottinger, M. A.
Holmes, D. J.
Martin, G. M.
Austad, S. N.
Item Type: 
Journal Article
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Journal Abbreviation: 
J. Gerontol. A Biol. Sci. Med. Sci.
Publication Date: 
2001-11
Publication Year: 
2001
Pages: 
B468-474
Volume: 
56
Issue: 
11
ISSN: 
1079-5006
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 11682567

Turabian/Chicago Citation

C. E. Ogburn, K. Carlberg, M. A. Ottinger, D. J. Holmes, G. M. Martin and S. N. Austad. 2001-11. "Exceptional cellular resistance to oxidative damage in long-lived birds requires active gene expression." The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 56: 11: B468-474.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 1079-5006 | volume = 56 | pages = B468-474 | last = Ogburn | first = C. E. | coauthors = Carlberg, K., Ottinger, M. A., Holmes, D. J., Martin, G. M., Austad, S. N. | title = Exceptional cellular resistance to oxidative damage in long-lived birds requires active gene expression | journal = The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences | date = 2001-11 | pmid = | pmc = }} </ref>