Exceptional longevity is associated with decreased reproduction
Language: 
English
Abstract: 

A number of leading theories of aging, namely The Antagonistic Pleiotropy Theory (Williams, 1957), The Disposable Soma Theory (Kirkwood, 1977) and most recently The Reproductive-Cell Cycle Theory (Bowen and Atwood, 2004, 2010) suggest a tradeoff between longevity and reproduction. While there has been an abundance of data linking longevity with reduced fertility in lower life forms, human data have been conflicting. We assessed this tradeoff in a cohort of genetically and socially homogenous Ashkenazi Jewish centenarians (average age ~100 years). As compared with an Ashkenazi cohort without exceptional longevity, our centenarians had fewer children (2.01 vs 2.53, p<0.0001), were older at first childbirth (28.0 vs 25.6, p<0.0001), and at last childbirth (32.4 vs 30.3, p<0.0001). The smaller number of children was observed for male and female centenarians alike. The lower number of children in both genders together with the pattern of delayed reproductive maturity is suggestive of constitutional factors that might enhance human life span at the expense of reduced reproductive ability.

Author(s): 
Tabatabaie, Vafa
Atzmon, Gil
Rajpathak, Swapnil N.
Freeman, Ruth
Barzilai, Nir
Crandall, Jill
Item Type: 
Journal Article
Publication Title: 
Aging
Journal Abbreviation: 
Aging (Albany NY)
Publication Date: 
2011-12
Publication Year: 
2011
Pages: 
1202-1205
Volume: 
3
Issue: 
12
ISSN: 
1945-4589
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 22199025 PMCID: PMC3273900

Turabian/Chicago Citation

Vafa Tabatabaie, Gil Atzmon, Swapnil N. Rajpathak, Ruth Freeman, Nir Barzilai and Jill Crandall. 2011-12. "Exceptional longevity is associated with decreased reproduction." Aging 3: 12: 1202-1205.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 1945-4589 | volume = 3 | pages = 1202-1205 | last = Tabatabaie | first = Vafa | coauthors = Atzmon, Gil, Rajpathak, Swapnil N., Freeman, Ruth, Barzilai, Nir, Crandall, Jill | title = Exceptional longevity is associated with decreased reproduction | journal = Aging | date = 2011-12 | pmid = | pmc = }} </ref>