Exceptional memory performance in the Long Life Family Study

Research to understand variability at the highest end of the cognitive performance distribution has been scarce. Our aim was to define a cognitive endophenotype based on exceptional episodic memory (EM) performance and to investigate familial aggregation of EM in families from the Long Life Family Study (LLFS). Using a sample of 1911 nondemented offspring of long-lived probands, we created a quantitative phenotype, EM (memory z ? 1.5), and classified LLFS families as EM and non-EM families based on the number of EM offspring. We then assessed differences in memory performance between LLFS relatives in the parental generation of EM families and those in non-EM families using multivariate analysis adjusted for APOE Apolipoprotein E genotype. LLFS relatives in the proband generation from EM families showed better EM performance than those from non-EM families (? = 0.74, standard error = 0.19, p = 1.4 ◊ 10(-4)). We demonstrated that there is a familial correlation of the EM endophenotype, suggesting that genetic variants might influence memory performance in long-lived families.

Barral, Sandra
Cosentino, Stephanie
Costa, Rosann
Andersen, Stacey L.
Christensen, Kaare
Eckfeldt, John H.
Newman, Anne B.
Perls, Thomas T.
Province, Michael A.
Hadley, Evan C.
Rossi, Winifred K.
Mayeux, Richard
Long Life Family Study
Item Type: 
Journal Article
Publication Title: 
Neurobiology of Aging
Journal Abbreviation: 
Neurobiol. Aging
Publication Date: 
Publication Year: 
Library Catalog: 
NCBI Published Medical (?)
PMID: 23759147 PMCID: PMC4095822

Turabian/Chicago Citation

Sandra Barral, Stephanie Cosentino, Rosann Costa, Stacey L. Andersen, Kaare Christensen, John H. Eckfeldt, Anne B. Newman, Thomas T. Perls, Michael A. Province, Evan C. Hadley, Winifred K. Rossi, Richard Mayeux and Long Life Family Study. 2013-11. "Exceptional memory performance in the Long Life Family Study." Neurobiology of Aging 34: 11: 2445-2448. 10.1016/j.neurobiolaging.2013.05.002.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.neurobiolaging.2013.05.002 | issn = 1558-1497 | volume = 34 | pages = 2445-2448 | last = Barral | first = Sandra | coauthors = Cosentino, Stephanie, Costa, Rosann, Andersen, Stacey L., Christensen, Kaare, Eckfeldt, John H., Newman, Anne B., Perls, Thomas T., Province, Michael A., Hadley, Evan C., Rossi, Winifred K., Mayeux, Richard, Long Life Family Study | title = Exceptional memory performance in the Long Life Family Study | journal = Neurobiology of Aging | date = 2013-11 | pmid = | pmc = }} </ref>