Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons
Language: 
English
Abstract: 

Reactive oxygen (RO) has been identified as an important effector in ageing and lifespan determination. The specific cell types, however, in which oxidative damage acts to limit lifespan of the whole organism have not been explicitly identified. The association between mutations in the gene encoding the oxygen radical metabolizing enzyme CuZn superoxide dismutase (SOD1) and loss of motorneurons in the brain and spinal cord that occurs in the life-shortening paralytic disease, Familial Amyotrophic Lateral Sclerosis (FALS; ref. 4), suggests that chronic and unrepaired oxidative damage occurring specifically in motor neurons could be a critical causative factor in ageing. To test this hypothesis, we generated transgenic Drosophila which express human SOD1 specifically in adult motorneurons. We show that overexpression of a single gene, SOD1, in a single cell type, the motorneuron, extends normal lifespan by up to 40% and rescues the lifespan of a short-lived Sod null mutant. Elevated resistance to oxidative stress suggests that the lifespan extension observed in these flies is due to enhanced RO metabolism. These results show that SOD activity in motorneurons is an important factor in ageing and lifespan determination in Drosophila.

Author(s): 
Parkes, T. L.
Elia, A. J.
Dickinson, D.
Hilliker, A. J.
Phillips, J. P.
Boulianne, G. L.
Item Type: 
Journal Article
Publication Title: 
Nature Genetics
Journal Abbreviation: 
Nat. Genet.
Publication Date: 
1998-06
Publication Year: 
1998
Pages: 
171-174
Volume: 
19
Issue: 
2
ISSN: 
1061-4036
DOI: 
10.1038/534
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 9620775

Turabian/Chicago Citation

T. L. Parkes, A. J. Elia, D. Dickinson, A. J. Hilliker, J. P. Phillips and G. L. Boulianne. 1998-06. "Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons." Nature Genetics 19: 2: 171-174. 10.1038/534.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1038/534 | issn = 1061-4036 | volume = 19 | pages = 171-174 | last = Parkes | first = T. L. | coauthors = Elia, A. J., Dickinson, D., Hilliker, A. J., Phillips, J. P., Boulianne, G. L. | title = Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons | journal = Nature Genetics | date = 1998-06 | pmid = | pmc = }} </ref>