Favorable glucose tolerance and lower prevalence of metabolic syndrome in offspring without diabetes mellitus of nonagenarian siblings: the Leiden longevity study
Language: 
English
Short Title: 
Favorable glucose tolerance and lower prevalence of metabolic syndrome in offspring without diabetes mellitus of nonagenarian siblings
Abstract: 

OBJECTIVES: To explore measures of metabolic syndrome and glucose metabolism in families with exceptional longevity. DESIGN: Case-control study. SETTING: A university hospital in Leiden, the Netherlands. PARTICIPANTS: One hundred twenty-one offspring of nonagenarian siblings, who were enriched for familial factors promoting longevity, and 113 of their partners. No subject had diabetes mellitus. MEASUREMENTS: Prevalence of metabolic syndrome was determined according to the criteria of the Third Report of the National Cholesterol Education Program. Glucose tolerance was assessed according to a 2-hour oral glucose tolerance test. RESULTS: The offspring of nonagenarians siblings had a lower prevalence of metabolic syndrome (P=.03), similar body composition, lower mean fasting blood glucose levels (4.99 vs 5.16 mmol/L; P=.01), lower mean fasting insulin levels (5.81 vs 6.75 mU/L; P=.04), a higher mean homeostasis model assessment of insulin sensitivity (0.78 vs 0.65; P=.02), and a more-favorable glucose tolerance (mean area under the receiver operating characteristic curve for glucose (13.2 vs 14.3; P=.007) than their partners. No significant differences were observed between the offspring and their partners in beta-cell function (insulogenic index 13.6 vs 12.5; P=.38). CONCLUSION: Despite similar body composition, the offspring of nonagenarian siblings showed a lower prevalence of metabolic syndrome and better glucose tolerance than their partners, centralizing the role of favorable glucose metabolism in familial longevity.

Author(s): 
Rozing, Maarten P.
Westendorp, Rudi G. J.
de Craen, Anton J. M.
Frˆlich, Marijke
de Goeij, Moniek C. M.
Heijmans, Bastiaan T.
Beekman, Marian
Wijsman, Carolien A.
Mooijaart, Simon P.
Blauw, Gerard-Jan
Slagboom, P. Eline
van Heemst, Diana
Leiden Longevity Study Group
Item Type: 
Journal Article
Publication Title: 
Journal of the American Geriatrics Society
Journal Abbreviation: 
J Am Geriatr Soc
Publication Date: 
2010-03
Publication Year: 
2010
Pages: 
564-569
Volume: 
58
Issue: 
3
ISSN: 
1532-5415
DOI: 
10.1111/j.1532-5415.2010.02725.x
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 20398121

Turabian/Chicago Citation

Maarten P. Rozing, Rudi G. J. Westendorp, Anton J. M. de Craen, Marijke Frˆlich, Moniek C. M. de Goeij, Bastiaan T. Heijmans, Marian Beekman, Carolien A. Wijsman, Simon P. Mooijaart, Gerard-Jan Blauw, P. Eline Slagboom, Diana van Heemst and Leiden Longevity Study Group. 2010-03. "Favorable glucose tolerance and lower prevalence of metabolic syndrome in offspring without diabetes mellitus of nonagenarian siblings: the Leiden longevity study." Journal of the American Geriatrics Society 58: 3: 564-569. 10.1111/j.1532-5415.2010.02725.x.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1111/j.1532-5415.2010.02725.x | issn = 1532-5415 | volume = 58 | pages = 564-569 | last = Rozing | first = Maarten P. | coauthors = Westendorp, Rudi G. J., de Craen, Anton J. M., Frˆlich, Marijke, de Goeij, Moniek C. M., Heijmans, Bastiaan T., Beekman, Marian, Wijsman, Carolien A., Mooijaart, Simon P., Blauw, Gerard-Jan, Slagboom, P. Eline, van Heemst, Diana, Leiden Longevity Study Group | title = Favorable glucose tolerance and lower prevalence of metabolic syndrome in offspring without diabetes mellitus of nonagenarian siblings: the Leiden longevity study | journal = Journal of the American Geriatrics Society | date = 2010-03 | pmid = | pmc = }} </ref>