Fluoxetine potentiates nitrazepam-induced behavioral sleep in young chicks
Language: 
English
Abstract: 

Nitrazepam (0.5-10 mg/kg, IP) dose dependently induced behavioral sleep in day-old chicks. Fluoxetine (0.1-1 mg/kg) did not produce sleep in the young birds, but the 5-HT reuptake inhibitor (0.1 and 0.5 mg/kg) potentiated nitrazepam (0.5 and 1.0 mg/kg)-induced hypnosis. Doses (0.5 and 1 mg/kg) of the benzodiazepine that did not produce sleep in any or all the chicks, when administered alone, induced sleep in some or all the chicks in the presence of fluoxetine (0.1 and 0.5 mg/kg). Ketanserin (0.5 and 2.5 mg/kg) effectively antagonized the effect of fluoxetine on nitrazepam-induced behavioral sleep. These results suggest that enhancement of 5-HT level by fluoxetine may be the mechanism involved in the potentiation of nitrazepam-induced sleep in the young chicks.

Author(s): 
Hussaini, I. M.
Musa, M. H.
Item Type: 
Journal Article
Publication Title: 
Physiology & Behavior
Journal Abbreviation: 
Physiol. Behav.
Publication Date: 
Feb-94
Publication Year: 
1994
Pages: 
391-393
Volume: 
55
Issue: 
2
ISSN: 
0031-9384
Library Catalog: 
PubMed
Extra: 
PMID: 8153184

Turabian/Chicago Citation

I. M. Hussaini and M. H. Musa. Feb-94. "Fluoxetine potentiates nitrazepam-induced behavioral sleep in young chicks." Physiology & Behavior 55: 2: 391-393.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 0031-9384 | volume = 55 | pages = 391-393 | last = Hussaini | first = I. M. | coauthors = Musa, M. H. | title = Fluoxetine potentiates nitrazepam-induced behavioral sleep in young chicks | journal = Physiology & Behavior | date = Feb-94 | pmid = | pmc = }} </ref>