Gender differences in the prospective associations of self-reported sleep quality with biomarkers of systemic inflammation and coagulation: findings from the Heart and Soul Study
Language: 
English
Short Title: 
Gender differences in the prospective associations of self-reported sleep quality with biomarkers of systemic inflammation and coagulation
Abstract: 

Systemic inflammation is proposed as a putative mechanism underlying the link between poor sleep and cardiovascular disease. The aim of present study was to investigate the cross-sectional and prospective associations of self-reported sleep quality with biomarkers of inflammation and coagulation implicated in coronary heart disease (CHD) and to explore whether these associations differed between men and women. To this end, measures of sleep quality and markers of inflammation, including circulating levels of interleukin-6 (IL-6), high-sensitivity C-reactive protein (CRP), and fibrinogen were assessed at baseline in 980 participants with established CHD and 626 at 5-year follow-up. In the sample as a whole, subjective sleep quality was unrelated to inflammatory markers in cross-sectional and prospective analyses. However, in gender stratified analyses, adjusting for age, ethnicity, education, body mass index, and regular snoring, poorer subjective sleep quality at baseline was prospectively associated with 5-year increases in IL-6 (b†=†0.14, SE†=†0.05, p†=†0.003), CRP (b†=†0.21, SE†=†0.09, p†=†0.02), and fibrinogen (b†=†18.02, SE†=†7.62, p†=†0.02) in women but not men. These associations remained independent of lifestyle/psychosocial factors, medical comorbidities, medication use, and cardiac function. Women who reported baseline sleep disturbances characterized by a tendency to wake up too early in the morning also showed significant 5-year increases in circulating IL-6 that withstood covariate adjustment. Further research is necessary to elucidate the pathways that underlie gender-specific associations between subjective sleep quality and markers of inflammation and coagulation as this may help clarify gender disparities in CHD.

Author(s): 
Prather, Aric A.
Epel, Elissa S.
Cohen, Beth E.
Neylan, Thomas C.
Whooley, Mary A.
Item Type: 
Journal Article
Publication Title: 
Journal of Psychiatric Research
Journal Abbreviation: 
J Psychiatr Res
Publication Date: 
2013-09
Publication Year: 
2013
Pages: 
1228-1235
Volume: 
47
Issue: 
9
ISSN: 
1879-1379
DOI: 
10.1016/j.jpsychires.2013.05.004
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 23746737 PMCID: PMC3864775

Turabian/Chicago Citation

Aric A. Prather, Elissa S. Epel, Beth E. Cohen, Thomas C. Neylan and Mary A. Whooley. 2013-09. "Gender differences in the prospective associations of self-reported sleep quality with biomarkers of systemic inflammation and coagulation: findings from the Heart and Soul Study." Journal of Psychiatric Research 47: 9: 1228-1235. 10.1016/j.jpsychires.2013.05.004.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.jpsychires.2013.05.004 | issn = 1879-1379 | volume = 47 | pages = 1228-1235 | last = Prather | first = Aric A. | coauthors = Epel, Elissa S., Cohen, Beth E., Neylan, Thomas C., Whooley, Mary A. | title = Gender differences in the prospective associations of self-reported sleep quality with biomarkers of systemic inflammation and coagulation: findings from the Heart and Soul Study | journal = Journal of Psychiatric Research | date = 2013-09 | pmid = | pmc = }} </ref>