A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel
Language: 
English
Abstract: 

Both poikilotherms and homeotherms live longer at lower body temperatures, highlighting a general role of temperature reduction in lifespan extension. However, the underlying mechanisms remain unclear. One prominent model is that cold temperatures reduce the rate of chemical reactions, thereby slowing the rate of aging. This view suggests that cold-dependent lifespan extension is simply a passive thermodynamic process. Here, we challenge this view in C. elegans by showing that genetic programs actively promote longevity at cold temperatures. We find that TRPA-1, a cold-sensitive TRP channel, detects temperature drop in the environment to extend lifespan. This effect requires cold-induced, TRPA-1-mediated calcium influx and a calcium-sensitive PKC that signals to the transcription factor DAF-16/FOXO. Human TRPA1 can functionally substitute for worm TRPA-1 in promoting longevity. Our results reveal a previously unrecognized function for TRP channels, link calcium signaling to longevity, and, importantly, demonstrate that genetic programs contribute to lifespan extension at cold temperatures.

Author(s): 
Xiao, Rui
Zhang, Bi
Dong, Yongming
Gong, Jianke
Xu, Tao
Liu, Jianfeng
Xu, X. Z. Shawn
Item Type: 
Journal Article
Publication Title: 
Cell
Journal Abbreviation: 
Cell
Publication Date: 
2/14/2013
Publication Year: 
2013
Pages: 
806-817
Volume: 
152
Issue: 
4
ISSN: 
1097-4172
DOI: 
10.1016/j.cell.2013.01.020
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 23415228 PMCID: PMC3594097

Turabian/Chicago Citation

Rui Xiao, Bi Zhang, Yongming Dong, Jianke Gong, Tao Xu, Jianfeng Liu and X. Z. Shawn Xu. 2/14/2013. "A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel." Cell 152: 4: 806-817. 10.1016/j.cell.2013.01.020.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.cell.2013.01.020 | issn = 1097-4172 | volume = 152 | pages = 806-817 | last = Xiao | first = Rui | coauthors = Zhang, Bi, Dong, Yongming, Gong, Jianke, Xu, Tao, Liu, Jianfeng, Xu, X. Z. Shawn | title = A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel | journal = Cell | date = 2/14/2013 | pmid = | pmc = }} </ref>