Genetics of schizophrenia and affective disorders
Language: 
English
Abstract: 

The molecular-genetic basis of non-mendelian, genetically influenced disorders (complex disorders) is beginning to be uncovered. Recently, major progress in localization and detection of disposition genes of schizophrenia and bipolar disorder was achieved. We provide a comprehensive overview of recent results of linkage and association studies in schizophrenia and bipolar disorder. Several disposition genes for schizophrenia (DTNBP1, NRG1, G72) were identified, whereas evidence for specific disposition genes in bipolar disorder is more limited. Multiple limitations of current research strategies in the search of disposition genes of complex disorders have to be considered; alternative phenotype definitions, genome-wide association studies and parallel investigation of epigenetic misregulations might overcome these limitations.

Author(s): 
Maier, W.
Zobel, A.
Rietschel, M.
Item Type: 
Journal Article
Publication Title: 
Pharmacopsychiatry
Journal Abbreviation: 
Pharmacopsychiatry
Publication Date: 
2003-11
Publication Year: 
2003
Pages: 
S195-202
Volume: 
36 Suppl 3
ISSN: 
0176-3679
DOI: 
10.1055/s-2003-45130
Library Catalog: 
PubMed
Extra: 
PMID: 14677079

Turabian/Chicago Citation

W. Maier, A. Zobel and M. Rietschel. 2003-11. "Genetics of schizophrenia and affective disorders." Pharmacopsychiatry 36 Suppl 3: S195-202. 10.1055/s-2003-45130.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1055/s-2003-45130 | issn = 0176-3679 | volume = 36 Suppl 3 | pages = S195-202 | last = Maier | first = W. | coauthors = Zobel, A., Rietschel, M. | title = Genetics of schizophrenia and affective disorders | journal = Pharmacopsychiatry | date = 2003-11 | pmid = | pmc = }} </ref>