Glutathione-S-transferase activity in malarial parasites
Language: 
English
Abstract: 

Glutathione-S-transferase (GST) activity has been detected in rodent (Plasmodium berghei, P. yoelii), simian (P. knowlesi) and human (P. falciparum) malarial parasites, and in different intraerythrocytic stages of P. knowlesi (schizont > ring > trophozoite). In chloroquine-resistant strains of rodent and human malarial parasites GST activity significantly increases compared to sensitive strains. Further, the increase in enzyme activity is directly related to drug pressure of resistant P. berghei. Complete inhibition of chloroquine-sensitive and resistant P. berghei glutathione-S-transferase activities was observed at 2.5 and 5. micrometer concentration of hemin, respectively. An inverse relationship was found between the heme level and enzyme activity of chloroquine-resistant and sensitive P. berghei. Chloroquine, artemisinin, and primaquine noticeably inhibited GST activity in P. knowlesi.

Author(s): 
Srivastava, P.
Puri, S. K.
Kamboj, K. K.
Pandey, V. C.
Item Type: 
Journal Article
Publication Title: 
Tropical medicine & international health: TM & IH
Journal Abbreviation: 
Trop. Med. Int. Health
Publication Date: 
Apr-99
Publication Year: 
1999
Pages: 
251-254
Volume: 
4
Issue: 
4
ISSN: 
1360-2276
Library Catalog: 
PubMed
Extra: 
PMID: 10320651

Turabian/Chicago Citation

P. Srivastava, S. K. Puri, K. K. Kamboj and V. C. Pandey. Apr-99. "Glutathione-S-transferase activity in malarial parasites." Tropical medicine & international health: TM & IH 4: 4: 251-254.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 1360-2276 | volume = 4 | pages = 251-254 | last = Srivastava | first = P. | coauthors = Puri, S. K., Kamboj, K. K., Pandey, V. C. | title = Glutathione-S-transferase activity in malarial parasites | journal = Tropical medicine & international health: TM & IH | date = Apr-99 | pmid = | pmc = }} </ref>