The good, the bad and the ugly - TFH cells in human health and disease
Language: 
English
Abstract: 

Antibody production is an important feature of the vertebrate immune system. Antibodies neutralize and clear pathogens, thereby protecting against infectious diseases. Such humoral immunity has great longevity, often persisting for the host's lifetime. Long-lived humoral immunity depends on help provided by CD4(+) T cells, namely T follicular helper (TFH) cells, which support the differentiation of antigen-specific B cells into memory and plasma cells. TFH cells are stringently regulated, as aberrant TFH cell activity is involved in immunopathologies such as autoimmunity, immunodeficiencies and lymphomas. The elucidation of the mechanisms that regulate TFH cell differentiation, function and fate should highlight targets for novel therapeutics.

Author(s): 
Tangye, Stuart G.
Ma, Cindy S.
Brink, Robert
Deenick, Elissa K.
Item Type: 
Journal Article
Publication Title: 
Nature Reviews. Immunology
Journal Abbreviation: 
Nat. Rev. Immunol.
Publication Date: 
2013-06
Publication Year: 
2013
Pages: 
412-426
Volume: 
13
Issue: 
6
ISSN: 
1474-1741
DOI: 
10.1038/nri3447
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 23681096

Turabian/Chicago Citation

Stuart G. Tangye, Cindy S. Ma, Robert Brink and Elissa K. Deenick. 2013-06. "The good, the bad and the ugly - TFH cells in human health and disease." Nature Reviews. Immunology 13: 6: 412-426. 10.1038/nri3447.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1038/nri3447 | issn = 1474-1741 | volume = 13 | pages = 412-426 | last = Tangye | first = Stuart G. | coauthors = Ma, Cindy S., Brink, Robert, Deenick, Elissa K. | title = The good, the bad and the ugly - TFH cells in human health and disease | journal = Nature Reviews. Immunology | date = 2013-06 | pmid = | pmc = }} </ref>