GUGULIPID: a natural cholesterol-lowering agent
Language: 
English
Short Title: 
GUGULIPID
Abstract: 

The resin of the Commiphora mukul tree has been used in Ayurvedic medicine for more than 2000 years to treat a variety of ailments. Studies in both animal models and humans have shown that this resin, termed gum guggul, can decrease elevated lipid levels. The stereoisomers E- and Z-guggulsterone have been identified as the active agents in this resin. Recent studies have shown that these compounds are antagonist ligands for the bile acid receptor farnesoid X receptor (FXR), which is an important regulator of cholesterol homeostasis. It is likely that this effect accounts for the hypolipidemic activity of these phytosteroids.

Author(s): 
Urizar, Nancy L.
Moore, David D.
Item Type: 
Journal Article
Publication Title: 
Annual Review of Nutrition
Journal Abbreviation: 
Annu. Rev. Nutr.
Publication Date: 
2003
Publication Year: 
2003
Pages: 
303-313
Volume: 
23
ISSN: 
0199-9885
DOI: 
10.1146/annurev.nutr.23.011702.073102
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 12626688

Turabian/Chicago Citation

Nancy L. Urizar and David D. Moore. 2003. "GUGULIPID: a natural cholesterol-lowering agent." Annual Review of Nutrition 23: 303-313. 10.1146/annurev.nutr.23.011702.073102.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1146/annurev.nutr.23.011702.073102 | issn = 0199-9885 | volume = 23 | pages = 303-313 | last = Urizar | first = Nancy L. | coauthors = Moore, David D. | title = GUGULIPID: a natural cholesterol-lowering agent | journal = Annual Review of Nutrition | date = 2003 | pmid = | pmc = }} </ref>