Hematopoietic capacity and exceptional survival: the Leiden Longevity Study
Language: 
English
Short Title: 
Hematopoietic capacity and exceptional survival
Abstract: 

OBJECTIVES: To assess whether familial longevity can be attributed to sustained hematopoietic capacity. DESIGN: Prospective follow-up study of two independent population-based cohorts. SETTING: The Leiden Longevity Study and the Leiden 85-plus Study. PARTICIPANTS: From the Leiden Longevity Study, 1,001 nonagenarians with familial longevity were included. As age-matched controls, 260 nonagenarians without familial longevity were used from the Leiden 85-plus Study. MEASUREMENTS: Hemoglobin, leukocytes, and thrombocytes were measured for all subjects with and without familial longevity. Standardized mortality ratios, linear regression, and left-censored Cox regression were used for statistical analysis. RESULTS: Mortality in nonagenarians with familial longevity was 28% lower than in nonagenarians from the general population (standardized mortality ratio=0.72, 95% confidence interval (CI)=0.65-0.79, P<.001). No differences were found between hemoglobin, leukocyte, and thrombocyte count in nonagenarians with and without familial longevity (all P>.30). Nonagenarians with familial longevity had greater mortality risk when anemia was present (sex-adjusted hazard ratio=1.71, 95% CI 1.41-2.07, P<.001). No relationship was found between leukocytes, thrombocytes, and mortality in either study group (all P>.20). CONCLUSION: Hematopoietic capacity cannot explain the significantly better survival of nonagenarians with familial longevity, but in those with familial longevity, anemia may contribute to mortality.

Author(s): 
Willems, Jorien M.
Trompet, Stella
Eline Slagboom, P.
de Craen, Anton J. M.
Westendorp, Rudi G. J.
Item Type: 
Journal Article
Publication Title: 
Journal of the American Geriatrics Society
Journal Abbreviation: 
J Am Geriatr Soc
Publication Date: 
2008-11
Publication Year: 
2008
Pages: 
2009-2013
Volume: 
56
Issue: 
11
ISSN: 
1532-5415
DOI: 
10.1111/j.1532-5415.2008.01933.x
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 18795986

Turabian/Chicago Citation

Jorien M. Willems, Stella Trompet, P. Eline Slagboom, Anton J. M. de Craen and Rudi G. J. Westendorp. 2008-11. "Hematopoietic capacity and exceptional survival: the Leiden Longevity Study." Journal of the American Geriatrics Society 56: 11: 2009-2013. 10.1111/j.1532-5415.2008.01933.x.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1111/j.1532-5415.2008.01933.x | issn = 1532-5415 | volume = 56 | pages = 2009-2013 | last = Willems | first = Jorien M. | coauthors = Trompet, Stella, Eline Slagboom, P., de Craen, Anton J. M., Westendorp, Rudi G. J. | title = Hematopoietic capacity and exceptional survival: the Leiden Longevity Study | journal = Journal of the American Geriatrics Society | date = 2008-11 | pmid = | pmc = }} </ref>