Hemodynamic effects of di-sec-butyl phenol, an anesthetic substituted phenol
Language: 
English
Abstract: 

Dose- and age-related hemodynamic effects were determined for an anesthetic substituted phenol, 2,6-di-sec-butyl phenol (DSB). DSB, 7.5 mg/kg, induced hypnosis in young rabbits and increased mean blood pressure to 170 +/- 14% and heart rate to 150 +/- 21% of control values. In elderly rabbits, 7.5 mg/kg DSB induced hypnosis, had no effect on blood pressure, but increased the heart rate to 130 +/- 2% of control. After ganglionic blockade with hexamethonium, 7.5 mg/kg DSB caused a decline in mean blood pressure (71 +/- 5% of control) without change in heart rate. DSB increased norepinephrine release from SH-SY5Y cells, a human neuroblastoma cell line (5.4 +/- 1.7% vs. 3.5 +/- 0.3%). DSB produced age-dependent elevation of mean blood pressure in rabbits, probably by causing release of catecholamines from the sympathetic nervous system.

Author(s): 
Ya Deau, Jacques T.
Heerdt, Paul M.
The, Andrew H. S.
Wang, Qingwen
Item Type: 
Journal Article
Publication Title: 
Pharmacology
Journal Abbreviation: 
Pharmacology
Publication Date: 
2006
Publication Year: 
2006
Pages: 
117-122
Volume: 
76
Issue: 
3
ISSN: 
0031-7012
DOI: 
10.1159/000090501
Library Catalog: 
PubMed
Extra: 
PMID: 16374073

Turabian/Chicago Citation

Jacques T. Ya Deau, Paul M. Heerdt, Andrew H. S. The and Qingwen Wang. 2006. "Hemodynamic effects of di-sec-butyl phenol, an anesthetic substituted phenol." Pharmacology 76: 3: 117-122. 10.1159/000090501.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1159/000090501 | issn = 0031-7012 | volume = 76 | pages = 117-122 | last = Ya Deau | first = Jacques T. | coauthors = Heerdt, Paul M., The, Andrew H. S., Wang, Qingwen | title = Hemodynamic effects of di-sec-butyl phenol, an anesthetic substituted phenol | journal = Pharmacology | date = 2006 | pmid = | pmc = }} </ref>