Hepatocurative and antioxidant profile of HP-1, a polyherbal phytomedicine
Language: 
English
Abstract: 

HP-1 a herbal formulation comprising of Phyllanthus niruri and extracts of Terminalia belerica, Terminalia chebula, Phyllanthus emblica and Tinospora cordifolia has been evaluated for hepatoprotective activity against carbon tetrachloride (CCl4) induced toxicity. Results show that HP-1 reversed the leakage of lactate dehydrogenase (LDH) and glutamate pyruvate transaminase (GPT) and prevented the depletion of glutathione (GSH) levels in a primary monolayer culture of rat hepatocytes (in vitro). HP-1 attenuated the serum toxicity as manifested in elevated levels of transaminases (glutamate oxaloacetate transaminase (GOT), and GPT) The antioxidative enzymes in liver (catalase and superoxide dismutase (SOD)) were restored to normal values after the oral administration of HP-1. HP-1 suppressed the formation of the superoxide anion radical and reduced CCl4 mediated lipid peroxidation (LPO). Silymarin and antioxidants (ascorbic acid, beta-carotene and alpha-tocopherol) were used for comparison. The present study showed that HP-1 is a potential hepatoprotective formulation with an additional attribute of being anti-peroxidative.

Author(s): 
Tasaduq, S. A.
Singh, K.
Sethi, S.
Sharma, S. C.
Bedi, K. L.
Singh, J.
Jaggi, B. S.
Johri, R. K.
Item Type: 
Journal Article
Publication Title: 
Human & Experimental Toxicology
Journal Abbreviation: 
Hum Exp Toxicol
Publication Date: 
2003-12
Publication Year: 
2003
Pages: 
639-645
Volume: 
22
Issue: 
12
ISSN: 
0960-3271
DOI: 
10.1191/0960327103ht406oa
Library Catalog: 
PubMed
Extra: 
PMID: 14992325

Turabian/Chicago Citation

S. A. Tasaduq, K. Singh, S. Sethi, S. C. Sharma, K. L. Bedi, J. Singh, B. S. Jaggi and R. K. Johri. 2003-12. "Hepatocurative and antioxidant profile of HP-1, a polyherbal phytomedicine." Human & Experimental Toxicology 22: 12: 639-645. 10.1191/0960327103ht406oa.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1191/0960327103ht406oa | issn = 0960-3271 | volume = 22 | pages = 639-645 | last = Tasaduq | first = S. A. | coauthors = Singh, K., Sethi, S., Sharma, S. C., Bedi, K. L., Singh, J., Jaggi, B. S., Johri, R. K. | title = Hepatocurative and antioxidant profile of HP-1, a polyherbal phytomedicine | journal = Human & Experimental Toxicology | date = 2003-12 | pmid = | pmc = }} </ref>