Herb-drug interaction of Epimedium sagittatum (Sieb. et Zucc.) maxim extract on the pharmacokinetics of sildenafil in rats
Language: 
English
Abstract: 

Epimedium sagittatum (Sieb. et Zucc.) Maxim is one of the herbs used to treat erectile dysfunction in Traditional Chinese Medicine. Sildenafil is a phosphodiesterase 5 inhibitor used to treat erectile dysfunction in Western Medicine. This study evaluates the herbal-drug interaction of Epimedium sagittatum extract on the pharmacokinetics of sildenafil in rats by ultra-performance liquid chromatography. The rat plasma was sampled from each anesthetized rat after pretreatment with 3-days Epimedium sagittatum extract (1/2 g/kg/day) and intravenous injection with sildenafil (10/30 mg/kg). The pharmacokinetic data demonstrate that the area under the concentration-time curve (AUC) of sildenafil (10 mg/kg) was significantly decreased in groups that received a high dose of Epimedium sagittatum extract. In conclusion, the study demonstrates that there was significant herb-drug interaction of Epimedium sagittatum extract on the pharmacokinetics of sildenafil at low and high daily doses, suggesting co-administration use of Epimedium sagittatum extract and sildenafil in clinical practice should be prevented due to possible herb-drug interactions.

Author(s): 
Hsueh, Thomas Y.
Wu, Yu-Tse
Lin, Lie-Chwen
Chiu, Allen W.
Lin, Chi-Hung
Tsai, Tung-Hu
Item Type: 
Journal Article
Publication Title: 
Molecules (Basel, Switzerland)
Journal Abbreviation: 
Molecules
Publication Date: 
2013
Publication Year: 
2013
Pages: 
7323-7335
Volume: 
18
Issue: 
6
ISSN: 
1420-3049
DOI: 
10.3390/molecules18067323
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 23792897

Turabian/Chicago Citation

Thomas Y. Hsueh, Yu-Tse Wu, Lie-Chwen Lin, Allen W. Chiu, Chi-Hung Lin and Tung-Hu Tsai. 2013. "Herb-drug interaction of Epimedium sagittatum (Sieb. et Zucc.) maxim extract on the pharmacokinetics of sildenafil in rats." Molecules (Basel, Switzerland) 18: 6: 7323-7335. 10.3390/molecules18067323.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.3390/molecules18067323 | issn = 1420-3049 | volume = 18 | pages = 7323-7335 | last = Hsueh | first = Thomas Y. | coauthors = Wu, Yu-Tse, Lin, Lie-Chwen, Chiu, Allen W., Lin, Chi-Hung, Tsai, Tung-Hu | title = Herb-drug interaction of Epimedium sagittatum (Sieb. et Zucc.) maxim extract on the pharmacokinetics of sildenafil in rats | journal = Molecules (Basel, Switzerland) | date = 2013 | pmid = | pmc = }} </ref>