Histone deacetylases enzyme, copper, and IL-8 levels in patients with Alzheimer's disease
Language: 
English
Abstract: 

BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive loss of cognitive abilities. Epigenetic modification, oxidative stress, and inflammation play an important role in the pathogenesis of the disease. We aimed to detect noninvasive peripheral biomarkers with a high degree of sensitivity and specificity in diagnosis and progression of AD. METHODS: A total of 25 elderly patients with AD and 25 healthy control participants were selected and subjected to cognitive assessment and laboratory measures including histone deacetylases (HDACs), copper, and interleukin 8 (IL-8) levels. RESULTS: The levels of HDACs, copper, and IL-8 were significantly higher in patients with AD (P < .001) and had a significant negative effect on all cognitive assessment tests. Receiver-operating curve (ROC) analysis revealed that HDACs and copper levels had higher sensitivity and specificity. CONCLUSIONS: Plasma levels of HDACs and copper may be used as peripheral biomarkers in diagnosis of AD, while IL-8 level could be a useful biomarker in following AD progression.

Author(s): 
Alsadany, Mohamad A.
Shehata, Hanan H.
Mohamad, Magda I.
Mahfouz, Riham G.
Item Type: 
Journal Article
Publication Title: 
American Journal of Alzheimer's Disease and Other Dementias
Journal Abbreviation: 
Am J Alzheimers Dis Other Demen
Publication Date: 
2013-02
Publication Year: 
2013
Pages: 
54-61
Volume: 
28
Issue: 
1
ISSN: 
1938-2731
DOI: 
10.1177/1533317512467680
Library Catalog: 
PubMed
Extra: 
PMID: 23242124

Turabian/Chicago Citation

Mohamad A. Alsadany, Hanan H. Shehata, Magda I. Mohamad and Riham G. Mahfouz. 2013-02. "Histone deacetylases enzyme, copper, and IL-8 levels in patients with Alzheimer's disease." American Journal of Alzheimer's Disease and Other Dementias 28: 1: 54-61. 10.1177/1533317512467680.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1177/1533317512467680 | issn = 1938-2731 | volume = 28 | pages = 54-61 | last = Alsadany | first = Mohamad A. | coauthors = Shehata, Hanan H., Mohamad, Magda I., Mahfouz, Riham G. | title = Histone deacetylases enzyme, copper, and IL-8 levels in patients with Alzheimer's disease | journal = American Journal of Alzheimer's Disease and Other Dementias | date = 2013-02 | pmid = | pmc = }} </ref>