The hyper-sentient addict: an exteroception model of addiction
Short Title: 
The hyper-sentient addict

BACKGROUND: Exteroception involves processes related to the perception of environmental stimuli important for an organism's ability to adapt to its environment. As such, exteroception plays a critical role in conditioned response. In addiction, behavioral and neuroimaging studies show that the conditioned response to drug-related cues is often associated with alterations in brain regions including the precuneus/posterior cingulate cortex, an important node within the default mode network dedicated to processes such as self-monitoring. OBJECTIVE: This review aimed to summarize the growing, but largely fragmented, literature that supports a central role of exteroceptive processes in addiction. METHODS: We performed a systematic review of empirical research via PubMed and Google Scholar with keywords including 'addiction', 'exteroception', 'precuneus', and 'self-awareness', to identify human behavioral and neuroimaging studies that report mechanisms of self-awareness in healthy populations, and altered self-awareness processes, specifically exteroception, in addicted populations. RESULTS: Results demonstrate that exteroceptive processes play a critical role in conditioned cue response in addiction and serve as targets for interventions such as mindfulness training. Further, a hub of the default mode network, namely, the precuneus, is (i) consistently implicated in exteroceptive processes, and (ii) widely demonstrated to have increased activation and connectivity in addicted populations. CONCLUSION: Heightened exteroceptive processes may underlie cue-elicited craving, which in turn may lead to the maintenance and worsening of substance use disorders. An exteroception model of addiction provides a testable framework from which novel targets for interventions can be identified.

DeWitt, Samuel J.
Ketcherside, Ariel
McQueeny, Tim M.
Dunlop, Joseph P.
Filbey, Francesca M.
Item Type: 
Journal Article
Publication Title: 
The American Journal of Drug and Alcohol Abuse
Journal Abbreviation: 
Am J Drug Alcohol Abuse
Publication Date: 
Publication Year: 
Library Catalog: 
PMID: 26154169 PMCID: PMC4732868

Turabian/Chicago Citation

Samuel J. DeWitt, Ariel Ketcherside, Tim M. McQueeny, Joseph P. Dunlop and Francesca M. Filbey. 2015. "The hyper-sentient addict: an exteroception model of addiction." The American Journal of Drug and Alcohol Abuse 41: 5: 374-381. 10.3109/00952990.2015.1049701.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.3109/00952990.2015.1049701 | issn = 1097-9891 | volume = 41 | pages = 374-381 | last = DeWitt | first = Samuel J. | coauthors = Ketcherside, Ariel, McQueeny, Tim M., Dunlop, Joseph P., Filbey, Francesca M. | title = The hyper-sentient addict: an exteroception model of addiction | journal = The American Journal of Drug and Alcohol Abuse | date = 2015 | pmid = | pmc = }} </ref>