Immunostimulatory action of AC II--an ayurvedic formulation useful in HIV
Language: 
English
Abstract: 

Immunostimulatory activity of AC II, a registered ayurvedic preparation prepared at Amala Ayurvedic Research Centre for treating HIV and AIDS is reported. AC II administration could significantly enhance the mitogen-induced proliferation of lymphocytes of spleen cells. It was also found to increase cell-mediated immune responses in normal and tumor-bearing control animals. Oral administration of AC II significantly enhanced Natural Killer cell activity in normal and tumor-bearing animals on the 7th day, which was observed earlier than the tumor-bearing control animals and normal animals. Antibody dependent cellular cytotoxicity (ADCC) was also increased in AC II treated normal and tumor-bearing animals. An early enhancement of antibody-dependent complement-mediated cytotoxicity was also observed by the administration of AC II in normal as well as tumor-bearing animals. Treatment with AC II elevated the levels of IL-2, TNF-alpha and IFN-gamma in normal mice. Administration of AC II was also found to increase the cytotoxic T lymphocyte production in EL4 treated mice. These studies support the use of this immune stimulatory preparation in HIV patients.

Author(s): 
Tharakan, Sheeja T.
Kuttan, Girija
Kuttan, Ramadasan
Kesavan, M.
Austin, null
Rajagopalan, K.
Item Type: 
Journal Article
Publication Title: 
Indian Journal of Experimental Biology
Journal Abbreviation: 
Indian J. Exp. Biol.
Publication Date: 
Jan 2008
Publication Year: 
2008
Pages: 
47-51
Volume: 
46
Issue: 
1
ISSN: 
0019-5189
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 18697571

Turabian/Chicago Citation

Sheeja T. Tharakan, Girija Kuttan, Ramadasan Kuttan, M. Kesavan, null Austin and K. Rajagopalan. Jan 2008. "Immunostimulatory action of AC II--an ayurvedic formulation useful in HIV." Indian Journal of Experimental Biology 46: 1: 47-51.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 0019-5189 | volume = 46 | pages = 47-51 | last = Tharakan | first = Sheeja T. | coauthors = Kuttan, Girija, Kuttan, Ramadasan, Kesavan, M., Austin, null, Rajagopalan, K. | title = Immunostimulatory action of AC II--an ayurvedic formulation useful in HIV | journal = Indian Journal of Experimental Biology | date = Jan 2008 | pmid = | pmc = }} </ref>