Immunosuppressive effects of gallic acid and chebulagic acid on CTL-mediated cytotoxicity
Language: 
English
Abstract: 

Gallic acid (GA) and chebulagic acid (CA) were isolated from the extract of a herbal medicine, kashi (myrobalans: the fruit of Terminalia chebula) as active principles that blocked the cytotoxic T lymphocyte (CTL)-mediated cytotoxicity. GA and CA inhibited the killing activity of CD8+ CTL clone at IC50 values of 30 microM and 50 microM, respectively. Granule exocytosis in response to anti-CD3 stimulation was also blocked by GA and CA at the equivalent concentrations.

Author(s): 
Hamada, S.
Kataoka, T.
Woo, J. T.
Yamada, A.
Yoshida, T.
Nishimura, T.
Otake, N.
Nagai, K.
Item Type: 
Journal Article
Publication Title: 
Biological & Pharmaceutical Bulletin
Journal Abbreviation: 
Biol. Pharm. Bull.
Publication Date: 
1997-09
Publication Year: 
1997
Pages: 
1017-1019
Volume: 
20
Issue: 
9
ISSN: 
0918-6158
Library Catalog: 
PubMed
Extra: 
PMID: 9331989

Turabian/Chicago Citation

S. Hamada, T. Kataoka, J. T. Woo, A. Yamada, T. Yoshida, T. Nishimura, N. Otake and K. Nagai. 1997-09. "Immunosuppressive effects of gallic acid and chebulagic acid on CTL-mediated cytotoxicity." Biological & Pharmaceutical Bulletin 20: 9: 1017-1019.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 0918-6158 | volume = 20 | pages = 1017-1019 | last = Hamada | first = S. | coauthors = Kataoka, T., Woo, J. T., Yamada, A., Yoshida, T., Nishimura, T., Otake, N., Nagai, K. | title = Immunosuppressive effects of gallic acid and chebulagic acid on CTL-mediated cytotoxicity | journal = Biological & Pharmaceutical Bulletin | date = 1997-09 | pmid = | pmc = }} </ref>